Comparative evaluation of the pathogenicity of Mycoplasma gallinaceum in chickens

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dc.contributor.author Adeyemi, Modupeore
dc.contributor.author Bwala, Dauda Garba
dc.contributor.author Abolnik, Celia
dc.date.accessioned 2018-06-11T11:06:54Z
dc.date.available 2018-06-11T11:06:54Z
dc.date.issued 2018
dc.description.abstract Mycoplasma gallinaceum is not among the most pathogenic mycoplasmas affecting poultry, but its continuous reisolation from flocks in South Africa displaying typical signs of mycoplasmosis prompted us to revisit its role in respiratory disease. Specific-pathogen-free white leghorn chickens were co-challenged with either M. gallinaceum (MGC) and QX-like infectious bronchitis virus (IBV), or the more virulent Mycoplasm gallisepticum (MG) and IBV. No clinical signs were observed apart from sneezing in chickens challenged with IBV, MGCþIBV, and MGþIBV. On postmortem examination, one bird each in the MGC þ IBV and IBV groups developed peritonitis or airsacculitis, respectively. In the tracheas, the MGþ IBV group showed the most severe ciliary damage with a mean ciliostatic score of 32.40 compared to scores of 26.83 and 20.4 for the MGC þ IBV and IBV groups, respectively. Corresponding tracheal lesions were recorded. Quantitation of the challenge pathogens by quantitative realtime PCR and real-time reverse transcriptase–PCR determined that MGC was shed in much higher titers from the trachea than MG, when co-infected with IBV. Interestingly, the presence of both MG and MGC appeared to enhance IBV replication in the tracheas of infected chickens, whereas the presence of IBV suppressed MG and MGC proliferation in the trachea. In general, the nonpathogenicity of M. gallinaceum in chickens was confirmed, but it was able to aggravate respiratory disease and pathogen proliferation with virulent QX-like IBV. en_ZA
dc.description.department Production Animal Studies en_ZA
dc.description.librarian am2018 en_ZA
dc.description.sponsorship Celia Abolnik’s South African National Research Foundation grant for rated scientists. Modupeore Adeyemi was supported by a University of Pretoria postdoctoral scholarship, and Dauda G. Bwala was supported by a University of Pretoria PhD scholarship. en_ZA
dc.description.uri http://www.aaapjournals.info/loi/avdi en_ZA
dc.identifier.citation Adeyemi, M., Bwala, D.G. & Abolnik, C. 2018, 'Comparative evaluation of the pathogenicity of Mycoplasma gallinaceum in chickens', Avian Deseases, vol. 62, no. 1, pp. 50-56. en_ZA
dc.identifier.issn 0005-2086 (print)
dc.identifier.issn 1938-4351 (online)
dc.identifier.other 10.1637/11743-081717-Reg.1
dc.identifier.uri http://hdl.handle.net/2263/65114
dc.language.iso en en_ZA
dc.publisher American Association of Avian Pathologists en_ZA
dc.rights © 2018 American Association of Avian Pathologists en_ZA
dc.subject Chickens en_ZA
dc.subject Pathogenicity en_ZA
dc.subject Virus en_ZA
dc.subject Disease en_ZA
dc.subject Poultry en_ZA
dc.subject Challenges en_ZA
dc.subject Protection en_ZA
dc.subject Infectious bronchitis virus (IBV) en_ZA
dc.subject Mycoplasma gallinaceum (MGC) en_ZA
dc.subject Mycoplasma gallisepticum (MG) en_ZA
dc.title Comparative evaluation of the pathogenicity of Mycoplasma gallinaceum in chickens en_ZA
dc.type Article en_ZA


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