Phase behavior of the polymer/drug system PLA/DEET : effect of PLA molar mass on subambient liquid-liquid phase separation

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dc.contributor.author Sungkapreecha, Chanita
dc.contributor.author Beily, Mark J.
dc.contributor.author Kressler, Jörg
dc.contributor.author Focke, Walter Wilhelm
dc.contributor.author Androsch, René
dc.date.accessioned 2018-06-01T11:17:57Z
dc.date.issued 2018-02
dc.description.abstract The phase behavior of binary mixtures of non-crystallizable racemic poly (d, l-lactic acid) (PDLLA) and the mosquito-repellent/drug N,N-diethyl-3-methylbenzamide (DEET) was analyzed with respect to the effect of the polymer molar mass on the liquid-liquid (L–L) phase separation characteristics, by cloud-point measurements and differential scanning calorimetry. The PDLLA/DEET system shows a subambient upper critical solution temperature (UCST), with the critical temperature decreasing and critical polymer concentration increasing with decreasing molar mass of PDLLA. The obtained L–L phase separation curves were used to estimate the temperature-dependence of the interaction parameter, confirming that the enhanced miscibility of the system components in case of low molar mass PDLLA is due to increased entropy of mixing. en_ZA
dc.description.department Chemical Engineering en_ZA
dc.description.embargo 2019-02-10
dc.description.librarian hj2018 en_ZA
dc.description.sponsorship Deutsche Forschungsgemeinschaft (DFG) (Grant AN 212/22). en_ZA
dc.description.uri http://www.elsevier.com/locate/tca en_ZA
dc.identifier.citation Sungkapreecha, C., Beily, M.J., Kressler, J. et al. 2018, 'Phase behavior of the polymer/drug system PLA/DEET : effect of PLA molar mass on subambient liquid-liquid phase separation', Thermochimica Acta, vol. 660, pp. 77-81. en_ZA
dc.identifier.issn 0040-6031 (print)
dc.identifier.issn 1872-762X (online)
dc.identifier.other 10.1016/j.tca.2017.12.021
dc.identifier.uri http://hdl.handle.net/2263/65073
dc.language.iso en en_ZA
dc.publisher Elsevier en_ZA
dc.rights © 2017 Elsevier B.V. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Thermochimica Acta. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. A definitive version was subsequently published in Thermochimica Acta, vol. 660, pp. 77-81, 2018. doi : 10.1016/j.tca.2017.12.021. en_ZA
dc.subject PLA/DEET phase diagram en_ZA
dc.subject Liquid-liquid phase separation en_ZA
dc.subject Flory-Huggins interaction parameter en_ZA
dc.subject Phase equilibria en_ZA
dc.subject Polystyrene en_ZA
dc.subject Scaffold en_ZA
dc.subject Fabrication en_ZA
dc.subject Drug delivery en_ZA
dc.subject Solvent systems en_ZA
dc.subject Molecular weight en_ZA
dc.subject Microporous membrane formation en_ZA
dc.title Phase behavior of the polymer/drug system PLA/DEET : effect of PLA molar mass on subambient liquid-liquid phase separation en_ZA
dc.type Postprint Article en_ZA


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