Impact of maternal HIV on umbilical cord lactate measurement at delivery in a South African labor ward

Loading...
Thumbnail Image

Authors

Allanson, Emma R.
Pattinson, Robert Clive
Nathan, Elizabeth A.
Dickinson, Jan E.

Journal Title

Journal ISSN

Volume Title

Publisher

Wiley

Abstract

OBJECTIVE : To assess umbilical artery lactate levels and perinatal outcomes among women with and without HIV infection. METHODS : The present prospective cohort study recruited women planning to undergo vaginal delivery at Kalafong Hospital, South Africa, between March 3 and November 12, 2014. Umbilical artery lactate levels were measured and perinatal outcome data were recorded. Outcome analyses were stratified by maternal HIV status, and a subgroup analysis was performed where women with a CD4 count below 350 × 106 cells/L were compared with women without HIV. RESULTS : In total, 936 women with singleton fetuses were enrolled. Maternal HIV status was available for 897 (95.8%) participants, of whom 202 (21.6%) had HIV infections. Overall, 186 (92.1%) women with HIV infections received prophylaxis or treatment. There was no difference between participants with and without HIV infections in the preterm delivery rate (P=0.770), mode of delivery (P=0.354), neonatal resuscitation rate (P=0.717), 1‐ or 5‐minute Apgar scores below 7 (P=0.353), or the rate of having an umbilical artery lactate level above 5.45 mmol/L (P=0.301). Similarly, there were no differences in outcomes in the subgroup analysis of women with a CD4 count below 350 × 106 cells/L. CONCLUSION : Umbilical artery lactate levels and perinatal outcomes were found to be comparable between patients with and without HIV infections in a South African setting.

Description

Keywords

Human immunodeficiency virus (HIV), Count, Outcomes, Meta analysis, Antiretroviral therapy (ART), Delivery, Lactate, Maternal, Middle income, Perinatal, South Africa (SA)

Sustainable Development Goals

Citation

Allanson, E.R., Pattinson, R.C., Nathan, E.A. & Dickinson, J.E. 2018, 'Impact of maternal HIV on umbilical cord lactate measurement at delivery in a South African labor ward', International Journal of Gynecology and Obstetrics, vol. 141, no. 3, pp. 366-370.