Cardiac diastolic function after recovery from pre-eclampsia

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dc.contributor.author Soma-Pillay, Priya
dc.contributor.author Louw, M.C.
dc.contributor.author Adeyemo, A.O.
dc.contributor.author Makin, J.A.
dc.contributor.author Pattinson, Robert Clive
dc.date.accessioned 2018-04-23T05:37:38Z
dc.date.available 2018-04-23T05:37:38Z
dc.date.issued 2018-01
dc.description.abstract BACKGROUND : Pre-eclampsia is associated with significant changes to the cardiovascular system during pregnancy. Eccentric and concentric remodelling of the left ventricle occurs, resulting in impaired contractility and diastolic dysfunction. It is unclear whether these structural and functional changes resolve completely after delivery. AIMS : The objective of the study was to determine cardiac diastolic function at delivery and one year post-partum in women with severe pre-eclampsia, and to determine possible future cardiovascular risk. METHODS : This was a descriptive study performed at Steve Biko Academic Hospital, a tertiary referral hospital in Pretoria, South Africa. Ninety-six women with severe preeclampsia and 45 normotensive women with uncomplicated pregnancies were recruited during the delivery admission. Seventy-four (77.1%) women in the pre-eclamptic group were classified as a maternal near miss. Transthoracic Doppler echocardiography was performed at delivery and one year post-partum. RESULTS : At one year post-partum, women with pre-eclampsia had a higher diastolic blood pressure (p = 0.001) and body mass index (p = 0.02) than women in the normotensive control group. Women with early onset pre-eclampsia requiring delivery prior to 34 weeks’ gestation had an increased risk of diastolic dysfunction at one year post-partum (RR 3.41, 95% CI: 1.11–10.5, p = 0.04) and this was irrespective of whether the patient had chronic hypertension or not. CONCLUSION : Women who develop early-onset pre-eclampsia requiring delivery before 34 weeks are at a significant risk of developing cardiac diastolic dysfunction one year after delivery compared to normotensive women with a history of a low-risk pregnancy. en_ZA
dc.description.department Cardiology en_ZA
dc.description.department Obstetrics and Gynaecology en_ZA
dc.description.librarian am2018 en_ZA
dc.description.uri http://www.cvja.co.za en_ZA
dc.identifier.citation Soma-Pillay, P., Louw, M.C., Adeyemo, A.O. et al. 2018, 'Cardiac diastolic function after recovery from pre-eclampsia', Cardiovascular Journal of Africa, vol. 29, no. 1, pp. 26-31. en_ZA
dc.identifier.issn 1995-1892 (print)
dc.identifier.issn 1680-0745 (online)
dc.identifier.other 10.5830/CVJA-2017-031
dc.identifier.uri http://hdl.handle.net/2263/64676
dc.language.iso en en_ZA
dc.publisher Clinics Cardive en_ZA
dc.rights © Clinics Cardive Publishing (Pty) Ltd en_ZA
dc.subject Pre-eclampsia en_ZA
dc.subject Diastolic function en_ZA
dc.subject Left ventricular remodelling en_ZA
dc.subject Pregnancy en_ZA
dc.title Cardiac diastolic function after recovery from pre-eclampsia en_ZA
dc.type Article en_ZA


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