Antibody responses to Marburg virus in Egyptian rousette bats and their role in protection against infection

Show simple item record Storm, Nadia Jansen van Vuren, Petrus Markotter, Wanda Paweska, Janusz Tadeusz 2018-03-12T07:01:26Z 2018-03-12T07:01:26Z 2018-02-10
dc.description.abstract Egyptian rousette bats (ERBs) are reservoir hosts for the Marburg virus (MARV). The immune dynamics and responses to MARV infection in ERBs are poorly understood, and limited information exists on the role of antibodies in protection of ERBs against MARV infection. Here, we determine the duration of maternal immunity to MARV in juvenile ERBs, and evaluate the duration of the antibody response to MARV in bats naturally or experimentally infected with the virus. We further explore whether antibodies in previously naturally exposed bats is fully protective against experimental reinfection with MARV. Maternal immunity was lost in juvenile ERBs by 5 months of age. Antibodies to MARV remained detectable in 67% of experimentally infected bats approximately 4 months post inoculation (p.i.), while antibodies to MARV remained present in 84% of naturally exposed bats at least 11 months after capture. Reinfection of seropositive ERBs with MARV produced an anamnestic response from day 5 p.i. Although PCR-defined viremia was present in 73.3% of reinfected ERBs, replicating virus was recovered from the serum of only one bat on day 3 p.i. The negative PCR results in the salivary glands, intestines, bladders and reproductive tracts of reinfected bats, and the apparent absence of MARV in the majority of swabs collected from these bats suggest that reinfection may only play a minor role in the transmission and maintenance of MARV amongst ERBs in nature. en_ZA
dc.description.department Medical Virology en_ZA
dc.description.department Microbiology and Plant Pathology en_ZA
dc.description.librarian am2018 en_ZA
dc.description.sponsorship The National Institute for Communicable Diseases, the National Research Foundation of South Africa (86228), the Poliomyelitis Research Foundation (13/54), and the University of Pretoria (postgraduate bursary). en_ZA
dc.description.uri en_ZA
dc.identifier.citation Storm, N., Van Vuren, P.J., Markotter, W. & Paweska, J.T. 2018, 'Antibody responses to Marburg virus in Egyptian rousette bats and their role in protection against infection', Viruses, 10, no. 2, art. no. 73, pp. 1-12. en_ZA
dc.identifier.issn 1999-4915 (online)
dc.identifier.other 10.3390/v10020073
dc.language.iso en en_ZA
dc.publisher MDPI Publishing en_ZA
dc.rights © 2018 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license ( en_ZA
dc.subject Antibody response en_ZA
dc.subject Maternal immunity en_ZA
dc.subject Immune duration en_ZA
dc.subject Reinfection en_ZA
dc.subject Viral shedding en_ZA
dc.subject South Africa (SA) en_ZA
dc.subject Egyptian rousette bat (ERB) en_ZA
dc.subject Marburg virus (MARV) en_ZA
dc.title Antibody responses to Marburg virus in Egyptian rousette bats and their role in protection against infection en_ZA
dc.type Article en_ZA

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