Reactive oxygen species and NOX enzymes are emerging as key players in cutaneous wound repair
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Date
Authors
Andre-Levigne, Dominik
Modarressi, Ali
Pepper, Michael Sean
Pittet-Cuenod, Brigitte
Journal Title
Journal ISSN
Volume Title
Publisher
MDPI Publishing
Abstract
Our understanding of the role of oxygen in cell physiology has evolved from its longrecognized
importance as an essential factor in oxidative metabolism to its recognition as an
important player in cell signaling. With regard to the latter, oxygen is needed for the generation of
reactive oxygen species (ROS), which regulate a number of different cellular functions including
differentiation, proliferation, apoptosis, migration, and contraction. Data specifically concerning the
role of ROS-dependent signaling in cutaneous wound repair are very limited, especially regarding
wound contraction. In this review we provide an overview of the current literature on the role of
molecular and reactive oxygen in the physiology of wound repair as well as in the pathophysiology
and therapy of chronic wounds, especially under ischemic and hyperglycemic conditions.
Description
Keywords
Reactive oxygen species, NADPH oxidase, NOX enzymes, Wound repair, Wound healing, Chronic wounds, Wound contraction, Re-epithelialization, Hyperbaric oxygen therapy, Oxidative stress
Sustainable Development Goals
Citation
Andre-Levigne, D., Modarressi, A., Pepper, M.S. et al. 2017, 'Reactive oxygen species and NOX enzymes are emerging as key players in cutaneous wound repair', International Journal of Molecular Sciences, vol. 18, art. no. 2149, pp. 1-28.