Our understanding of the role of oxygen in cell physiology has evolved from its longrecognized
importance as an essential factor in oxidative metabolism to its recognition as an
important player in cell signaling. With regard to the latter, oxygen is needed for the generation of
reactive oxygen species (ROS), which regulate a number of different cellular functions including
differentiation, proliferation, apoptosis, migration, and contraction. Data specifically concerning the
role of ROS-dependent signaling in cutaneous wound repair are very limited, especially regarding
wound contraction. In this review we provide an overview of the current literature on the role of
molecular and reactive oxygen in the physiology of wound repair as well as in the pathophysiology
and therapy of chronic wounds, especially under ischemic and hyperglycemic conditions.
Silk has been used in textile production for centuries and in medicine, as sutures for decades. Sericin and fibroin are the two primary silk proteins. Silk has been shown to improve wound healing. Copper ions have also ...
OBJECTIVES : Whole plants of Boerhavia diffusa L. are widely used medicine in Ghana and other tropical countries, for the treatment of wounds and other ailments. The aim of the study was to determine the ability of sequential ...
Management of open lower limb fractures with soft tissue defects can be a technically challenging orthopaedic problem.
Limited availability of orthoplastic services means that alternatives to the fix and flap concept are ...