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dc.contributor.author | Lauritzen, Hilde B.![]() |
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dc.contributor.author | Larose, Tricia L.![]() |
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dc.contributor.author | Oien, Torbjorn![]() |
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dc.contributor.author | Sandanger, Torkjel M.![]() |
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dc.contributor.author | Odland, Jon Oyvind![]() |
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dc.contributor.author | Van de Bor, Margot![]() |
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dc.contributor.author | Jacobsen, Geir W.![]() |
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dc.date.accessioned | 2018-02-09T12:16:13Z | |
dc.date.available | 2018-02-09T12:16:13Z | |
dc.date.issued | 2018-01-18 | |
dc.description | Additional file 1: Supplementary figures, tables and information. | en_ZA |
dc.description.abstract | BACKGROUND : Prenatal exposure to persistent organic pollutants (POPs), may influence offspring weight gain. More prospective epidemiological studies are needed to compliment the growing body of evidence from animal studies. METHODS : Serum from 412 pregnant Norwegian and Swedish women participating in a Scandinavian prospective cohort study were collected in 1986–88, and analyses of two perfluoroalkyl substances (PFASs) and five organochlorines (OCs) were conducted. We used linear and logistic regression models with 95% confidence intervals (CIs) to evaluate the associations between maternal serum POP concentrations at 17–20 weeks of gestation and child overweight/obesity (body mass index (BMI) ≥ 85th percentile) at 5-year follow-up. Results were further stratified by country after testing for effect modification. We also assessed potential non-monotonic dose-response (NMDR) relationships. RESULTS : In adjusted linear models, we observed increased BMI-for-age-and-sex z-score (β = 0.18, 95% CI: 0.01–0.35), and increased triceps skinfold z-score (β = 0.15, 95% CI: 0.02–0.27) in children at 5-year follow-up per ln-unit increase in maternal serum perfluorooctane sulfonate (PFOS) concentrations. We observed increased odds for child overweight/obesity (BMI ≥ 85th percentile) for each ln-unit increase in maternal serum PFOS levels (adjusted OR: 2.04, 95% CI: 1.11–3.74), with stronger odds among Norwegian children (OR: 2.96, 95% CI: 1.42–6.15). We found similar associations between maternal serum perfluorooctanoate (PFOA) concentrations and child overweight/obesity. We found indications of NMDR relationships between PFOS and polychlorinated biphenyl (PCB) 153 and child overweight/obesity among Swedish children. CONCLUSION : We found positive associations between maternal serum PFAS concentrations and child overweight/obesity at 5-year follow-up, particularly among Norwegian participants. We observed some evidence for NMDR relationships among Swedish participants. | en_ZA |
dc.description.department | School of Health Systems and Public Health (SHSPH) | en_ZA |
dc.description.librarian | am2018 | en_ZA |
dc.description.sponsorship | Grants from the Liaison Committee between the Central Norway Regional Health Authority (RHA) and the Norwegian University of Science and Technology (NTNU). | en_ZA |
dc.description.uri | https://ehjournal.biomedcentral.com | en_ZA |
dc.identifier.citation | Lauritzen, H.B., Larose, T.L., Oien, T. et al. 2018, 'Prenatal exposure to persistent organic pollutants and child overweight/obesity at 5-year follow-up : a prospective cohort study', Environmental Health, vol. 17, art. no. 9, pp. 1-12. | en_ZA |
dc.identifier.issn | 1476-069X | |
dc.identifier.other | 10.1186/s12940-017-0338-x | |
dc.identifier.uri | http://hdl.handle.net/2263/63914 | |
dc.language.iso | en | en_ZA |
dc.publisher | BioMed Central | en_ZA |
dc.rights | © The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/). | en_ZA |
dc.subject | Perfluoroalkyl substances | en_ZA |
dc.subject | Organochlorines | en_ZA |
dc.subject | Childhood obesity | en_ZA |
dc.subject | Non-monotonic dose-response relationship | en_ZA |
dc.subject | Pregnancy | en_ZA |
dc.subject | Endocrine disrupting chemicals | en_ZA |
dc.subject | Skinfolds | en_ZA |
dc.subject | Plasma | en_ZA |
dc.subject | Triceps | en_ZA |
dc.subject | Pregnancy | en_ZA |
dc.subject | Adolescents | en_ZA |
dc.subject | Risk | en_ZA |
dc.subject | Obesity | en_ZA |
dc.subject | Postnatal growth | en_ZA |
dc.subject | Skinfold thickness | en_ZA |
dc.subject | Endocrine disrupting chemicals | en_ZA |
dc.subject | Body mass index (BMI) | en_ZA |
dc.title | Prenatal exposure to persistent organic pollutants and child overweight/obesity at 5-year follow-up : a prospective cohort study | en_ZA |
dc.type | Article | en_ZA |