When is it appropriate to model transmission of tuberculosis using a dose response model?

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Authors

Strydom, Duayne
Küsel, R.R. (Ralf)
Craig, Ian Keith

Journal Title

Journal ISSN

Volume Title

Publisher

Elsevier

Abstract

The risk of transmission of tuberculosis (TB) in confined spaces is analyzed using the Gammaitoni and Nucci model and its variant, a dose response model. The dose response model with its additional parameters has the benefit of taking the immune status and susceptibility of an individual into account, as a separate term from the generation parameter. It is shown via a sensitivity analysis and a model algebraic identifiability analysis that there is little benefit in using the more complex dose response model unless the number of infectious TB particles in the air can be measured. This is because the uncertainties associated with the additional dose response model parameters are otherwise lumped into the parameter representing the generation of infectious TB particles.

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Keywords

Tuberculosis (TB), Risk of transmission model, Risk in transmission control, Quanta

Sustainable Development Goals

Citation

Strydom, D., Küsel, R.R. & Craig, I.K. 2017, 'When is it appropriate to model transmission of tuberculosis using a dose response model?', IFAC-PapersOnLine, vol. 50, no. 2, pp. 31-36.