Major involvement of bacterial components in rheumatoid arthritis and its accompanying oxidative stress, systemic inflammation and hypercoagulability

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dc.contributor.author Pretorius, Etheresia
dc.contributor.author Akeredolu, Oore-Ofe
dc.contributor.author Soma, Prashilla
dc.contributor.author Kell, Douglas B.
dc.date.accessioned 2018-01-16T07:52:56Z
dc.date.available 2018-01-16T07:52:56Z
dc.date.issued 2017-02
dc.description.abstract We review the evidence that infectious agents, including those that become dormant within the host, have a major role to play in much of the etiology of rheumatoid arthritis and the inflammation that is its hallmark. This occurs in particular because they can produce cross-reactive (auto-)antigens, as well as potent inflammagens such as lipopolysaccharide that can themselves catalyze further inflammagenesis, including via β-amyloid formation. A series of observables coexist in many chronic, inflammatory diseases as well as rheumatoid arthritis. They include iron dysregulation, hypercoagulability, anomalous morphologies of host erythrocytes, and microparticle formation. Iron dysregulation may be responsible for the periodic regrowth and resuscitation of the dormant bacteria, with concomitant inflammagen production. The present systems biology analysis benefits from the philosophical idea of “coherence,” that reflects the principle that if a series of ostensibly unrelated findings are brought together into a self-consistent narrative, that narrative is thereby strengthened. As such, we provide a coherent and testable narrative for the major involvement of (often dormant) bacteria in rheumatoid arthritis. en_ZA
dc.description.department Physiology en_ZA
dc.description.librarian hj2018 en_ZA
dc.description.sponsorship The Manchester Centre for Synthetic Biology of Fine and Speciality Chemicals (SYNBIOCHEM) (BBSRC grant BB/M017702/1). en_ZA
dc.description.uri http://ebm.sagepub.com en_ZA
dc.identifier.citation Pretorius, E., Akeredolu, O.-O., Soma, P. & Kell, D.B. 2017, 'Major involvement of bacterial components in rheumatoid arthritis and its accompanying oxidative stress, systemic inflammation and hypercoagulability', Experimental Biology and Medicine, vol. 242, no. 4, pp. 355-373. . en_ZA
dc.identifier.issn 1535-3702 (print)
dc.identifier.issn 1535-3699 (online)
dc.identifier.other 10.1177/1535370216681549
dc.identifier.uri http://hdl.handle.net/2263/63561
dc.language.iso en en_ZA
dc.publisher Sage en_ZA
dc.rights © 2016 by the Society for Experimental Biology and Medicine. This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http://www.creativecommons.org/licenses/by/4.0/). en_ZA
dc.subject Rheumatoid arthritis en_ZA
dc.subject Dormancy en_ZA
dc.subject Iron dysregulation en_ZA
dc.subject Atopobiosis en_ZA
dc.subject Infectious agents en_ZA
dc.subject Lipopolysaccharides en_ZA
dc.subject Proteus en_ZA
dc.subject Inflammation en_ZA
dc.subject Comorbidities en_ZA
dc.title Major involvement of bacterial components in rheumatoid arthritis and its accompanying oxidative stress, systemic inflammation and hypercoagulability en_ZA
dc.type Article en_ZA


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