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dc.contributor.author | Reddy, Deshika![]() |
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dc.contributor.author | Choonara, Yahya E.![]() |
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dc.contributor.author | Kumar, Pradeep![]() |
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dc.contributor.author | Govender, Mershen![]() |
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dc.contributor.author | Indermun, Sunaina![]() |
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dc.contributor.author | Du Toit, Lisa C.![]() |
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dc.contributor.author | Meyer, Leith Carl Rodney![]() |
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dc.contributor.author | Pillay, Viness![]() |
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dc.date.accessioned | 2018-01-16T05:45:52Z | |
dc.date.issued | 2017-02 | |
dc.description.abstract | The purpose of this study was to design and evaluate the performance of an Ultra-fast Disintegrating Wafer (U-D-WAF) loaded with highly water soluble diphenhydramine hydrochloride (DPH) through the oramucosa of the Large White Pig model. For the first time this work explored the oramucosivity of the U-D-WAF by detailed molecular modeling of the matrix on buccal tissue in order to mechanistically deduce the mucodhesivity. The U-D-WAF was formulated using a blend of hydroxypropylcellulose, poly(acrylic) acid, sodium starch glycolate and β –cyclodextrin in accordance with a Box-Benkhen experimental design for optimization prior to ex vivo permeation and in vivo release studies in the Large White Pig. Molecular simulation studies assess the mucoadhesivity of the U-D-WAF to the oramucosa. A mean Drug Entrapment Efficiency of 72.96 ± 4.32%, disintegration time of 29.33 ± 15.91 s and drug release after 60 s of 86.32 ± 20.37% was recorded. Ex vivo permeation studies revealed cumulative drug permeation of 86.32 ± 20.34% 60 s after onset. In vivo evaluation of the optimized U-D-WAF had a Cmax = 59 μgL−1 approximately 300 s after administration. The ultrafast disintegration of the U-D-WAF matrix with desirable mucoadhesivity in in vitro and in vivo studies makes it suitable for effective and rapid oramucosal drug delivery. | en_ZA |
dc.description.department | Paraclinical Sciences | en_ZA |
dc.description.embargo | 2018-02-20 | |
dc.description.librarian | hj2018 | en_ZA |
dc.description.sponsorship | The National Research Foundation (NRF) and the Technology Innovation Agency (TIA) of South Africa. | en_ZA |
dc.description.uri | http://www.elsevier.com/locate/jddst | en_ZA |
dc.identifier.citation | Reddy, D., Choonara, Y.E., Kumar, P. et al. 2017, 'In vivo evaluation of an Ultra-fast Disintegrating Wafer matrix : a molecular simulation approach to the ora-mucoadhesivity', Journal of Drug Delivery Science and Technology, vol. 37, pp. 123-133. | en_ZA |
dc.identifier.issn | 0165-1889 (print) | |
dc.identifier.issn | 1879-1743 (online) | |
dc.identifier.other | 10.1016/j.jddst.2016.12.008 | |
dc.identifier.uri | http://hdl.handle.net/2263/63557 | |
dc.language.iso | en | en_ZA |
dc.publisher | Elsevier | en_ZA |
dc.rights | © 2016 Elsevier B.V. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Journal of Drug Delivery Science and Technology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. A definitive version was subsequently published in Journal of Drug Delivery Science and Technology, vol. 37, pp. 123-133, 2017. doi : 10.1016/j.jddst.2016.12.008. | en_ZA |
dc.subject | Ultra-fast disintegrating wafer (U-D-WAF) | en_ZA |
dc.subject | Diphenhydramine hydrochloride (DPH) | en_ZA |
dc.subject | Mucoadhesivity | en_ZA |
dc.subject | Molecular modeling | en_ZA |
dc.subject | In vivo permeabilty | en_ZA |
dc.subject | Rapid disintegration | en_ZA |
dc.subject | Wafer matrix | en_ZA |
dc.subject | Oramucosal drug delivery | en_ZA |
dc.title | In vivo evaluation of an Ultra-fast Disintegrating Wafer matrix : a molecular simulation approach to the ora-mucoadhesivity | en_ZA |
dc.type | Postprint Article | en_ZA |