68Ga-PSMA-11 PET/CT in primary staging of prostate carcinoma : preliminary results on differences between black and white South-Africans

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dc.contributor.author Sathekge, Mike Machaba
dc.contributor.author Lengana, Thabo
dc.contributor.author Maes, Alex
dc.contributor.author Vorster, Mariza
dc.contributor.author Zeevaart, Jan Rijn
dc.contributor.author Lawal, Ismaheel
dc.contributor.author Ebenhan, Thomas
dc.contributor.author Van de Wiele, Christophe
dc.date.accessioned 2018-01-12T07:13:01Z
dc.date.available 2018-01-12T07:13:01Z
dc.date.issued 2018-02
dc.description.abstract PURPOSE : The incidence of prostate cancer is 60% higher and the mortality rate is two- to three-times greater in black versus white men. We report on differences in 68Ga-PSMA-11 PET/CT imaging findings in 77 black South-African (BSAs) and 18 white South-African (WSAs) treatment-naïve primary prostate carcinoma (PPC) patients. METHODS : 68Ga-PSMA-11 PET/CT imaging findings were compared to histological, biochemical and morphological imaging data. Patients were grouped into three Gleason grade groups (GG), GG 1 (scores 3 + 3 and 3 + 4), GG2 (scores 4 + 3 and 4 + 4) and GG3 (scores 9 and 10), and the PSA difference among the groups was determined. Inter-racial difference in SUVmax of the primary tumor as well as its correlation with serum PSA were also determined. RESULTS : Ninety-three out of 95 PPC where readily identified on 68Ga-PSMA-11 PET/CT imaging. Median PPC SUVmax and serum PSA values proved significantly higher (p = 0.033 and p = 0.003) in GG3 patients (median 16.4 and 180 ng/ml) when compared to GG1 patients (median 9.6 and 25.1 ng/ml) or GG2 patients (median 8.8 and 46.2 ng/ml). SUVmax significantly correlated with serum PSA-values (r = 0.377 (p = 0.0001)). Age, frequency of lymph node involvement and distant metastases, and GGs (p ≥ 0.153) were similar in BSAs and WSAs, both median serum PSA-values as well as SUVmax values proved significantly higher in BSAs when compared to WSAs, respectively, 81.6 ng/ml versus 14.5 ng/ ml (p = 0.0001) and 11.9 versus 4.38 (p = 0.004). Moreover, Gleason-score normalized median SUVmax values proved 2.5 times higher in BSAs when compared to WSAs (p = 0.005). CONCLUSION : SUVmax values proved significantly related to GG and to be significantly higher in BSAs when compared to WSAs. Also, SUVmax significantly correlated with serum PSA values, which was significantly higher in BSAs when compared with WSAs. en_ZA
dc.description.department Nuclear Medicine en_ZA
dc.description.librarian am2018 en_ZA
dc.description.uri http://link.springer.com/journal/259 en_ZA
dc.identifier.citation Sathekge, M., Lengana, T., Maes, A. et al. 68Ga-PSMA-11 PET/CT in primary staging of prostate carcinoma : preliminary results on differences between black and white South-Africans. European Journal of Nuclear Medicine and Molecular Imaging (2018) 45: 226-234. https://doi.org/10.1007/s00259-017-3852-8. en_ZA
dc.identifier.issn 1619-7070 (print)
dc.identifier.issn 1619-7089 (online)
dc.identifier.other 10.1007/s00259-017-3852-8
dc.identifier.uri http://hdl.handle.net/2263/63512
dc.language.iso en en_ZA
dc.publisher Springer en_ZA
dc.rights © The Author(s) 2017. This article is an open access publication. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http:// creativecommons.org/licenses/by/4.0/). en_ZA
dc.subject 68Ga-PSMA en_ZA
dc.subject Prostate carcinoma en_ZA
dc.subject Racial differences en_ZA
dc.subject Black South-African (BSAs) en_ZA
dc.subject White South-African (WSAs) en_ZA
dc.subject Primary prostate carcinoma (PPC) en_ZA
dc.subject Prostate-specific membrane antigen (PSMA) en_ZA
dc.subject Positron emission tomography (PET) en_ZA
dc.title 68Ga-PSMA-11 PET/CT in primary staging of prostate carcinoma : preliminary results on differences between black and white South-Africans en_ZA
dc.type Article en_ZA


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