dc.contributor.author |
Ebenhan, Thomas
|
|
dc.contributor.author |
Mokaleng, Botshelo B.
|
|
dc.contributor.author |
Venter, Jacobus Daniel
|
|
dc.contributor.author |
Kruger, Hendrik Gert
|
|
dc.contributor.author |
Zeevaart, Jan Rijn
|
|
dc.contributor.author |
Sathekge, Mike Machaba
|
|
dc.date.accessioned |
2017-10-31T11:06:29Z |
|
dc.date.available |
2017-10-31T11:06:29Z |
|
dc.date.issued |
2017-09 |
|
dc.description.abstract |
The study assessed a radiolabeled depsipeptide conjugate (68Ga-DOTA-TBIA101) for its
potential as an imaging agent targeting infection or infection-associated inflammation. 68Ga-labeled
DOTA-TBIA101 imaging was performed in (NZR1) healthy rabbits; (NZR2) rabbits bearing
muscular sterile inflammation and Staphylococcus aureus (SA) infection; and (NZR3) rabbits
infected with Mycobacterium tuberculosis (MTB) combined with a subcutaneous scruff infection
of SA in the same animal. All animals were imaged using a PET/CT scanner at 5 and 60 min
post injection. Images showed elevated accumulation of 68Ga-DOTA-TBIA101 in the sterile
muscular inflammation site (T/NT ratio = 2.6 0.37 (5 min) and 2.8 2.3 (60 min)) and
muscles infected with MTB (T/NT ratio = 2.6 0.35 (5 min) and 2.8 0.16 (60 min)). The findings
suggest that 68Ga-DOTA-TBIA101-PET/CT may detect MTB-associated inflammation, although more
foundational studies need to be performed to rationalize the diagnostic value of this technique. |
en_ZA |
dc.description.department |
Nuclear Medicine |
en_ZA |
dc.description.librarian |
am2017 |
en_ZA |
dc.description.sponsorship |
The authors thank the Nuclear Technologies in Medicine and the Biosciences Initiative,
managed by the South African Nuclear Energy Corporation and funded by the Department of Science and
Technology (DST). |
en_ZA |
dc.description.uri |
http://www.mdpi.com/journal/molecules |
en_ZA |
dc.identifier.citation |
Ebenhan, T., Mokaleng, B.B., Venter, J.D., Kruger, H.G., Zeevaart, J.R. & Sathekge, M. 2017, 'Preclinical assessment of a 68Ga-DOTA-functionalized depsipeptide as a radiodiagnostic infection imaging agent', Molecules, vol. 22, no. 9, art. no. 1403, pp. 1-14. |
en_ZA |
dc.identifier.issn |
1420-3049 (online) |
|
dc.identifier.other |
10.3390/molecules22091403 |
|
dc.identifier.uri |
http://hdl.handle.net/2263/62988 |
|
dc.language.iso |
en |
en_ZA |
dc.publisher |
MDPI Publishing |
en_ZA |
dc.rights |
© 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access
article distributed under the terms and conditions of the Creative Commons Attribution
(CC BY) license. |
en_ZA |
dc.subject |
DOTA-TBIA101 |
en_ZA |
dc.subject |
Depsipeptides |
en_ZA |
dc.subject |
Infection |
en_ZA |
dc.subject |
Inflammation |
en_ZA |
dc.subject |
68Ga/68Ge generator |
en_ZA |
dc.subject |
PET/CT imaging |
en_ZA |
dc.subject |
Tuberculosis (TB) |
en_ZA |
dc.title |
Preclinical assessment of a 68Ga-DOTA-functionalized depsipeptide as a radiodiagnostic infection imaging agent |
en_ZA |
dc.type |
Article |
en_ZA |