Mammary analogue secretory carcinoma (MASC) is a rare and recently described tumour of the salivary glands. MASC has similar
histomorphological and immunohistochemical features of secretory carcinoma of the breast. MASC can be mistaken for other salivary
gland tumours, especially acinic cell carcinoma. A 28-year-old man was diagnosed with a rare salivary gland tumour in Pretoria, South
Africa (SA). To our knowledge, a report of MASC in SA has not previously been published. The surgeons dealing with salivary gland
tumours should be aware of the clinical presentation. Current treatment is similar to that of other salivary gland malignancies.