Genomic epidemiology of global VIM-producing Enterobacteriacea

Show simple item record Matsumura, Yasufumi Peirano, Gisele Devinney, Rebekah Bradford, Patricia A. Motyl, Mary R. Adams, Mark D. Chen, Liang Kreiswirth, Barry Pitout, Johann D.D. 2017-08-28T11:52:19Z 2017-08
dc.description.abstract BACKGROUND : International data on the molecular epidemiology of Enterobacteriaceae with VIM carbapenemases are limited. METHODS : We performed short read (Illumina) WGS on a global collection of 89 VIM-producing clinical Enterobacteriaceae (2008–14). RESULTS : VIM-producing (11 varieties within 21 different integrons) isolates were mostly obtained from Europe. Certain integrons with blaVIM were specific to a country in different species and clonal complexes (CCs) (In87, In624, In916 and In1323), while others had spread globally among various Enterobacteriaceae species (In110 and In1209). Klebsiella pneumoniae was the most common species (n = 45); CC147 from Greece was the most prevalent clone and contained In590-like integrons with four different blaVIMs. Enterobacter cloacae complex was the second most common species and mainly consisted of Enterobacter hormaechei (Enterobacter xiangfangensis, subsp. steigerwaltii and Hoffmann cluster III). CC200 (from Croatia and Turkey), CC114 (Croatia, Greece, Italy and the USA) and CC78 (from Greece, Italy and Spain) containing blaVIM-1 were the most common clones among the E. cloacae complex. CONCLUSIONS : This study highlights the importance of surveillance programmes using the latest molecular techniques in providing insight into the characteristics and global distribution of Enterobacteriaceae with blaVIMs. en_ZA
dc.description.department Medical Microbiology en_ZA
dc.description.embargo 2018-08-30
dc.description.librarian hj2017 en_ZA
dc.description.sponsorship The John Mung Program from Kyoto University, Japan (Y. M.), a research grant from the Calgary Laboratory Services (no. 10015169; J. D. D. P.) and federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services under Award Numbers U19AI110819 (M. D. A.) and R01AI090155 (to B. K.). en_ZA
dc.description.uri en_ZA
dc.identifier.citation Matsumura, Y., Peirano, G., Devinney, R., Bradford, P.A., Motyl, M.R., Adams, M.D., Chen, L., Kreiswirth, B. & Pitout, J.D.D. 2017, 'Genomic epidemiology of global VIM-producing Enterobacteriaceae', Journal of Antimicrobial Chemotherapy, vol. 72, no. 8, pp. 2249-2258. en_ZA
dc.identifier.issn 0305-7453 (print)
dc.identifier.issn 1460-2091 (online)
dc.identifier.other 10.1093/jac/dkx148
dc.language.iso en en_ZA
dc.publisher Oxford University Press en_ZA
dc.rights © The Author 2017. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Journal of Antimicrobial Chemotherapy following peer review. The definitive publisher-authenticated version is : 'Genomic epidemiology of global VIM-producing Enterobacteriaceae', Journal of Antimicrobial Chemotherapy, vol. 72, no. 8, pp. 2249-2258, 2017. doi : 10.1093/jac/dkx148, is available online at : en_ZA
dc.subject Epidemiology en_ZA
dc.subject Integrons en_ZA
dc.subject Medical en_ZA
dc.subject Surveillance en_ZA
dc.subject Spain en_ZA
dc.subject Pneumoniae en_ZA
dc.subject Klebsiella en_ZA
dc.subject Italy en_ZA
dc.subject Greece en_ZA
dc.subject Genome en_ZA
dc.subject Molecular en_ZA
dc.subject Enterobacteriaceae en_ZA
dc.subject Enterobacter cloacae en_ZA
dc.subject Clone cells en_ZA
dc.subject Croatia en_ZA
dc.subject Enterobacter en_ZA
dc.title Genomic epidemiology of global VIM-producing Enterobacteriacea en_ZA
dc.type Postprint Article en_ZA

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