Aphrodisiac potentials of the ethanol extract of Aloe barbadensis Mill. root in male Wistar rats

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dc.contributor.author Erhabor, Joseph O.
dc.contributor.author Idu, MacDonald
dc.date.accessioned 2017-08-23T05:45:58Z
dc.date.available 2017-08-23T05:45:58Z
dc.date.issued 2017-07-11
dc.description.abstract BACKGROUND : Aloe barbadensis (AB) is a short stemmed succulent medicinal herb that is being used by locals in Nigeria to enhance libido. Therefore this study evaluates the aphrodisiac potential and acute toxicological effect of A. barbadensis (AB) root in male Wistar rats. METHODS : Aphrodisiac potential was determined following the oral administration of graded doses (100, 200 and 400 mg/kg) of ethanol extract of A. barbadensis root. Sildenafil citrate (Viagra) and distilled water served as positive and negative controls respectively. Sexual behavioural parameters (mounting and intromission frequencies, mounting, intromission and ejaculatory latencies) were observed. Serum testosterone and cholesterol concentrations were also progressively monitored on days 1, 7 and 14. The acute toxicological evaluation of the plant were based on any onset behavioural changes and mortality respectively. RESULTS : The findings from the sexual behavioural study indicated that the ethanol extract of A. barbadensis significantly increased mounting frequency and intromission frequency but significantly decreased mount and intromission latencies in a dose dependent manner particularly on day 1 and 14. The ethanol extract also prolonged ejaculatory latency. The testosterone and cholesterol concentrations were also increased as the dose increased particularly on day 1 and 7. The lowest dose of 100 mg/kg showed the best aphrodisiac effect. The toxicity studies showed that there were no acute behavioural changes with zero mortality. CONCLUSION : The increased blood testosterone and cholesterol concentrations by the ethanol extract of A. barbadensis can probably be said to be the possible mechanisms of action for its aphrodisiac property. The plant may also be used to treat hypotestosteronemia following its ability to increase testosterone. These findings therefore give backing to the acclaimed local use of A. barbadensis root as an aphrodisiac in males. en_ZA
dc.description.department Paraclinical Sciences en_ZA
dc.description.librarian am2017 en_ZA
dc.description.sponsorship This work was supported by the University Research and Publication Unit of the University of Benin with a thesis write up grant to Joseph O. Erhabor (JOE). en_ZA
dc.description.uri http://www.biomedcentral.com/bmccom/plementalternmed en_ZA
dc.identifier.citation Erhabor, J.O. & Idu, M. 2017, 'Aphrodisiac potentials of the ethanol extract of Aloe barbadensis Mill. root in male Wistar rats', BMC Complement​ary and Alternativ​e Medicine, vol. 17, art. no. 360, pp. 1-10. en_ZA
dc.identifier.issn 1472-6882
dc.identifier.other 10.1186/s12906-017-1866-1
dc.identifier.uri http://hdl.handle.net/2263/61762
dc.language.iso en en_ZA
dc.publisher BioMed Central en_ZA
dc.rights © The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License. en_ZA
dc.subject Aphrodisiac en_ZA
dc.subject Medicinal plants en_ZA
dc.subject Aloe barbadensis en_ZA
dc.subject Male sexual behaviour en_ZA
dc.subject Testosterone en_ZA
dc.subject Traditional medicine en_ZA
dc.subject Ethanol extract en_ZA
dc.subject Erectile dysfunction en_ZA
dc.subject Copulatory behavior en_ZA
dc.subject Herbs en_ZA
dc.subject Aqueous extract en_ZA
dc.subject Leaf extract en_ZA
dc.subject Toxicity en_ZA
dc.subject Hypertension en_ZA
dc.title Aphrodisiac potentials of the ethanol extract of Aloe barbadensis Mill. root in male Wistar rats en_ZA
dc.type Article en_ZA


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