The association between COMT rs4680 and 5-HTTLPR genotypes and concussion history in South African rugby union players

Show simple item record Mc Fie, Sarah Abrahams, Shameemah Patricios, Jonathan Speridon Suter, Jason Posthumus, Michael September, Alison V. 2017-07-19T10:47:50Z 2018-04
dc.description.abstract The objective was to investigate the relationship between Catechol-O-methyltransferase (COMT) rs4680 and serotonin-transporter-linked polymorphic region (5-HTTLPR) genotypes with concussion history and personality traits. Rugby players (“all levels”: n = 303), from high schools (“junior”, n = 137), senior amateur, and professional teams (“senior”, n = 166), completed a self-reported concussion history questionnaire, Cloninger’s Tridimensional Personality Questionnaire, and donated a DNA sample. Participants were allocated into control (non-concussed, n = 140), case (all) (previous suspected or diagnosed concussions, n = 163), or case (diagnosed only) (previous diagnosed concussion, n = 140) groups. COMT rs4680 Val/Val genotypes were over-represented in controls in all levels (P = 0.013, OR:2.00, 95% CI:1.15–3.57) and in juniors (P = 0.003, OR:3.57, 95% CI:1.45–9.09). Junior Val/Val participants displayed increased “anticipatory worry” (P = 0.023). The 5-HTTLPR low expressing group was under-represented in controls when all levels were considered (P = 0.032; OR:2.02, 95% CI:1.05–3.90) and in juniors (P = 0.021; OR:3.36, 95% CI:1.16–9.72). Junior 5-HTTLPR low and intermediate expressing groups displayed decreased “harm avoidance” (P = 0.009), “anticipatory worry” (P = 0.041), and “fear of uncertainty” (P < 0.001). This study provides preliminary indications that personality associated genetic variants can influence concussion in rugby. en_ZA
dc.description.department Sports Medicine en_ZA
dc.description.embargo 2019-10-01
dc.description.librarian hj2017 en_ZA
dc.description.sponsorship The South African National Research Foundation (A.V.S., grant number 90942), (M.P., grant numbers 93416:2015, 85534:2015). The South African National Research Foundation and the University of Cape Town funded S.A. and S.M. en_ZA
dc.description.uri en_ZA
dc.identifier.citation Sarah Mc Fie, Shameemah Abrahams, Jon Patricios, Jason Suter, Michael Posthumus & Alison V. September (2018): The association between COMT rs4680 and 5- HTTLPR genotypes and concussion history in South African rugby union players, Journal of Sports Sciences, 36(8):920-933. DOI: 10.1080/02640414.2017.1346274. en_ZA
dc.identifier.issn 1466-447X (online)
dc.identifier.issn 0264-0414 (print)
dc.identifier.other 10.1080/02640414.2017.1346274
dc.language.iso en en_ZA
dc.publisher Routledge en_ZA
dc.rights © 2017 Informa UK Limited, trading as Taylor & Francis Group. This is an electronic version of an article published in Journal of Sports Sciences, vol. 36, no. 8, pp. 920-933, 2018. doi : 10.1080/02640414.2017.1346274. Journal of Sports Sciences is available online at : http://www.tandfonline.comloi/rjsp20. en_ZA
dc.subject Concussion en_ZA
dc.subject Rugby en_ZA
dc.subject Personality en_ZA
dc.subject Catechol-O-methyltransferase (COMT) en_ZA
dc.subject Serotonin transporter gene (SLC6A4) en_ZA
dc.title The association between COMT rs4680 and 5-HTTLPR genotypes and concussion history in South African rugby union players en_ZA
dc.type Postprint Article en_ZA

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