Vitamin D status and its consequences for health in South Africa

Show simple item record Norval, Mary Coussens, Anna K. Wilkinson, Robert J. Bornman, Liza Lucas, Robyn M. Wright, C.Y. (Caradee) 2017-06-10T08:34:26Z 2017-06-10T08:34:26Z 2016-10-18
dc.description.abstract In this review, reports were retrieved in which vitamin D status, as assessed by serum 25-hydroxyvitamin D [25(OH)D] levels, was measured in South African population groups with varied skin colours and ethnicities. Healthy children and adults were generally vitamin D-sufficient [25(OH)D level >50 nmol/L] but the majority of those aged above 65 years were deficient. A major role for exposure to solar ultraviolet radiation (UVR) in determining 25(OH)D levels was apparent, with the dietary contribution being minor. Limited data exist regarding the impact of recent changes in lifestyles on vitamin D status, such as urbanisation. With regard to disease susceptibility, 11 of 22 relevant publications indicated association between low 25(OH)D levels and disease, with deficiency most notably found in individuals with tuberculosis and HIV-1. Information on the relationship between vitamin D receptor variants and ethnicity, disease or treatment response in the South African population groups demonstrated complex interactions between genetics, epigenetics and the environment. Whether vitamin D plays an important role in protection against the range of diseases that currently constitute a large burden on the health services in South Africa requires further investigation. Only then can accurate advice be given about personal sun exposure or dietary vitamin D supplementation. en_ZA
dc.description.department Geography, Geoinformatics and Meteorology en_ZA
dc.description.librarian am2017 en_ZA
dc.description.sponsorship Anna K. Coussens is supported by the Academy of Science of South Africa (Sydney Brenner Fellowship), Medical Research Council of South Africa-SHIP-02-2013; Robert J. Wilkinson by the Wellcome Trust Grants 084323 and 104893, Francis Crick Institute 10218, Medical Research Council of South Africa, National Research Foundation of South Africa 96841 and US National Institutes of Health U19AI111276; Liza Bornman by the Cancer Association of South Africa and the National Research Foundation of South Africa, Robyn M. Lucas by an Australian National Health and Medical Research Council Senior Research Fellowship 1107343; and Caradee Y. Wright by the Medical Research Council of South Africa and the National Research Foundation of South Africa. en_ZA
dc.description.uri en_ZA
dc.identifier.citation Norval, M, Coussens, AK, Wilkinson, RJ, Bornman, L, Lucas, RM & Wright, CY 2016, 'Vitamin D status and its consequences for health in South Africa', International Journal of Environmental Research and Public Health, vol. 13, art. no. 1019, pp. 1-22. en_ZA
dc.identifier.issn 1660-4601
dc.identifier.other 10.3390/ijerph13101019
dc.language.iso en en_ZA
dc.publisher MDPI Publishing en_ZA
dc.rights © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license. en_ZA
dc.subject HIV-1 en_ZA
dc.subject Vitamin D receptor en_ZA
dc.subject Sun exposure en_ZA
dc.subject Tuberculosis (TB) en_ZA
dc.title Vitamin D status and its consequences for health in South Africa en_ZA
dc.type Article en_ZA

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