The toxin of Clostridium chauvoei

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dc.contributor.author Mason, J.H.
dc.contributor.editor Du Toit, P.J.
dc.date.accessioned 2017-06-06T13:09:56Z
dc.date.available 2017-06-06T13:09:56Z
dc.date.created 2017
dc.date.issued 1936
dc.description The articles have been scanned in colour with a HP Scanjet 5590; 300dpi. Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format. en_ZA
dc.description.abstract (1) In culture filtrates of Cl. chauvoei two antigens have been demonstrated (a) a toxin, and (b) a heat stable antigen. The toxin can best be demonstrated by injecting filtrate intradermically into guinea-pigs, particularly if adrenalin is incorporated in the filtrate. The presence of the heat stable antigen is proved if toxin-free (heated) bacilli are injected into sheep; after a suitable interval these are immune to the inoculation of living culture. (2) The toxin, or its atoxic modification, stimulates the formation of antitoxin when injected into animals, whereas the heat stable antigen does not do so. (3) The toxin is neutralizable by homologous antitoxin, by Cl. septicum antitoxin and to a slight extent by the sera of some normal bovines and rabbits. (4) The toxins of four different strains of Cl. chauvoei have been found to be indistinguishable serologically. (5) There is no correlation between the amount of circulating antitoxin in an animal and the power of the animal to resist the inoculation of living culture. (6) There is a correlation between the amount of circulating antitoxin in an animal and its power of resisting toxin, injected intravenously or intradermically. (7) The evidence points to the heat stable antigen being the important one in the production of immunity to Cl. chauvoei culture. en_ZA
dc.identifier.citation Mason, JH 1936, 'The toxin of Clostridium chauvoei’, Onderstepoort Journal of Veterinary Science and Animal Industry, vol. 7, no. 2, pp. 433-482. en_ZA
dc.identifier.issn 0330-2465
dc.identifier.uri http://hdl.handle.net/2263/60913
dc.language.iso en en_ZA
dc.publisher Pretoria : The Government Printer en_ZA
dc.rights © 1936 ARC - Onderstepoort and Faculty of Veterinary Science, University of Pretoria (original). © 2017 University of Pretoria. Dept. of Library Services (digital). en_ZA
dc.subject Veterinary medicine en_ZA
dc.subject.lcsh Veterinary medicine -- South Africa
dc.title The toxin of Clostridium chauvoei en_ZA
dc.type Article en_ZA


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