Since the turn of the millennium Zimbabwe has witnessed a raft of socio-economic and political challenges, exacerbated by the devastating effects of the HIV and Aids pandemic. This diminished the government’s ability to provide safety nets to vulnerable groups. The responsibility for orphan care has been shifted to the community, which has become the core focus of intervention initiatives by devising local-level coping mechanisms to deal with the orphan care crisis. The study explored the contribution of social entrepreneurship in meeting the needs of orphans in the Mberengwa district. The study concludes that the income-generating projects based on social entrepreneurship principles in Mberengwa play an important role in poverty alleviation and social protection, and particularly in meeting the needs of orphans. However, this cannot be achieved without the supportive role of government in promoting private-public partnerships.