Systolic function evaluated with cardiovascular magnetic resonance imaging in HIV-infected patients
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Date
Authors
Stoltz, Anton Carel
Du Plessis, Andre
Andronikou, Savvas
Swart, Anelia
Scholtz, Leonie
Khan, Aneesah
Moosa, Aqeela
Journal Title
Journal ISSN
Volume Title
Publisher
AOSIS OpenJournals
Abstract
BACKGROUND : Of all areas worldwide, sub-Saharan Africa is worst affected by the HIV and/or
AIDS epidemic. Cardiovascular manifestations are very common and are a powerful
contributor to mortality, but often go undetected. Cardiovascular magnetic resonance (CMR)
is the most reliable method of assessing cardiac function and morphology and, with this in
mind, we initiated a cross-sectional study comparing CMR-determined morphological and
functional parameters in asymptomatic HIV-infected patients who were not yet on treatment
and early in the disease, with HIV-uninfected control patients.
OBJECTIVES : To ascertain whether there were any morphological abnormalities or systolic
functional impairments on CMR in untreated asymptomatic HIV-infected patients, compared
with HIV-uninfected control individuals.
METHODS : The CMR studies were performed using a 1.5-T whole-body clinical magnetic
resonance 16-channel scanner (Achieva, Philips Medical Systems, Best, The Netherlands),
using a cardiac five-element phased-array receiver coil (SENSE coil). Functional assessment
was performed on 36 HIV-infected patients and the findings compared with 35 HIV-uninfected
control patients who were matched for age and sex.
RESULTS : There was no significant difference in systolic function between the HIV-uninfected
and the HIV-infected patients. The left ventricular end diastolic mass (LVEDM) was slightly
higher in the HIV-infected group, but this was statistically insignificant.
CONCLUSION : No significant differences were found regarding the CMR systolic functional
analysis and morphological parameters between the HIV-infected and the healthy volunteers.
Description
Keywords
Patients, Human immunodeficiency virus (HIV), Cardiovascular magnetic resonance (CMR), Left ventricular end diastolic mass (LVEDM)
Sustainable Development Goals
Citation
Scholtz L, Du Plessis A, Andronikou S, et al. Systolic function evaluated with cardiovascular magnetic resonance
imaging in HIV-infected patients. S Afr J Rad. 2016;20(2), a1044. http://dx.doi.org/10.4102/sajr.v20i2.1044.