Acute intermittent porphyria mimicking Guillain–Barré syndrome in a HIV patient

Show simple item record Soma, Prashilla Ueckermann, Veronica Sasikumar, S.S. (Sunayana) Mashoeshoe, K.S. (Sam) 2017-05-30T07:20:05Z 2017-05-30T07:20:05Z 2016-01 en
dc.description.abstract The diagnosis of porphyria remains challenging as the condition is characterized by a myriad of clinical and biochemical features. More importantly, an acute attack is associated with increased morbidity and mortality. Misdiagnosis of porphyria poses an ongoing problem. We describe a 42-year-old Black female South African patient who presented to Steve Biko Academic Hospital in Pretoria, on the 16 July 2014 with a clinical problem of acute paraparesis. On admission, she had absent reflexes, bilateral cranial nerve VII fallout, patchy sensory fallout and faecal incontinence. When her magnetic resonance imaging of the brain and cervical spine showed no signs suggestive of acute disseminated encephalomyelitis, a diagnosis of Guillain–Barré syndrome was made. On the 21 July her condition deteriorated to the point where she needed ventilator support. She also developed a pulmonary embolism and was treated. Due to deterioration of her condition, urine was sent for porphobilinogen test. This was clearly positive. The diagnosis of acute intermittent porphyria was eventually made. This case highlights the complexity related to the diagnosis of porphyria. It confirms that the diagnosis is often incidental and in a vast majority of patients, neurological complications preceded the final biochemical diagnosis. en_ZA
dc.description.department Physiology en
dc.description.department Internal Medicine en
dc.description.department Neurology en
dc.description.uri en
dc.identifier.citation Soma, P., Ueckermann, V., Sasikumar, S. & Mashoeshoe, K.S. 2016, 'Acute intermittent porphyria mimicking Guillain–Barré syndrome in a HIV patient', HIV and AIDS Review, vol. 15, no. 4, pp. 180-181. en
dc.identifier.issn 1732-2707 (online) en
dc.identifier.issn 1730-1270 (print) en
dc.identifier.other 10.1016/j.hivar.2016.11.006 en
dc.language.iso English en
dc.publisher Elsevier en
dc.rights © 2016 Polish AIDS Research Society. Published by Elsevier Sp. z o.o. All rights reserved. Notice : this is the author's version of a work that was accepted for publication in HIV and AIDS Review. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. A definitive version was subsequently published in HIV and AIDS Review, vol. 15, no. 4, pp. 180-181, 2016. doi : 10.1016/j.hivar.2016.11.006. en
dc.subject Diagnosis en
dc.subject Porphyria en
dc.subject Acute intermittent porphyria (AIP) en
dc.subject Human immunodeficiency virus (HIV) en
dc.subject Guillain–Barré syndrome en
dc.title Acute intermittent porphyria mimicking Guillain–Barré syndrome in a HIV patient en
dc.type Postprint Article en

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