Antimicrobial, antioxidant and cytotoxicity studies of medicinal plants used in the treatment of sexually transmitted diseases

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dc.contributor.author Tshikalange, Thilivhali Emmanuel
dc.contributor.author Mamba, P.
dc.contributor.author Adebayo, S.A.
dc.date.accessioned 2017-05-15T08:34:06Z
dc.date.available 2017-05-15T08:34:06Z
dc.date.issued 2016-11-15
dc.description.abstract CONTEXT : The World Health Organization reported that more than 1 million sexually transmitted infections (STIs) are acquired daily, with an estimated 357 million new infections caused by either chlamydia, gonorrhoea, syphilis or trichomoniasis. Aim: The present study was aimed to evaluate antimicrobial, antioxidant and cytotoxicity activities of ethanol extracts of ten ethnobotanical selected plant species used to treat STD’s and related symptoms. Methods: The determination of antimicrobial susceptibility of plant extracts was done using the broth micro-dilution assay against five microorganisms. The free radical scavenging activity was determined by using DPPH (2, 2-diphenyly-1-picrylhydrazyl). Cytotoxicity activity of the plant extracts was done on Vero African monkey cells lines with 2, 3-bis [2-methoxy-4-nitro-5-sulfophenyl]-2H-tetrazolium-5-carboxanilide (XTT) reagents. Results: Our results suggest that extracts of Acacia karroo and Rhoicissus tridentata subsp. cuneifolia are potential candidates with a good antimicrobial, antioxidant and low cytotoxicity activities. This results may support the anecdotal claims for the use of the selected plant species to treat venereal diseases. en_ZA
dc.description.department Plant Production and Soil Science en_ZA
dc.description.librarian am2017 en_ZA
dc.description.sponsorship The National Research Foundation (NRF Grant no: 99022) en_ZA
dc.description.uri http://www.ijppr.com/ en_ZA
dc.identifier.citation Tshikalange, TE, Mamba, P & Adebayo, SA 2016, 'Antimicrobial, antioxidant and cytotoxicity studies of medicinal plants used in the treatment of sexually transmitted diseases', International Journal of Pharmacognosy and Phytochemical Research, vol. 8, no. 11, pp. 1891-1895. en_ZA
dc.identifier.issn 0975-4873
dc.identifier.uri http://hdl.handle.net/2263/60451
dc.language.iso en en_ZA
dc.publisher INDIA Publishers en_ZA
dc.rights INDIA Publishers en_ZA
dc.subject Antimicrobial en_ZA
dc.subject Antioxidant en_ZA
dc.subject Cytotoxicity en_ZA
dc.subject Sexually transmitted disease (STD) en_ZA
dc.title Antimicrobial, antioxidant and cytotoxicity studies of medicinal plants used in the treatment of sexually transmitted diseases en_ZA
dc.type Article en_ZA


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