Antimicrobial, antioxidant and cytotoxicity studies of medicinal plants used in the treatment of sexually transmitted diseases
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Date
Authors
Tshikalange, Thilivhali Emmanuel
Mamba, P.
Adebayo, Salmon A.
Journal Title
Journal ISSN
Volume Title
Publisher
INDIA Publishers
Abstract
CONTEXT : The World Health Organization reported that more than 1 million sexually transmitted infections (STIs) are acquired daily, with an estimated 357 million new infections caused by either chlamydia, gonorrhoea, syphilis or trichomoniasis. Aim: The present study was aimed to evaluate antimicrobial, antioxidant and cytotoxicity activities of ethanol extracts of ten ethnobotanical selected plant species used to treat STD’s and related symptoms. Methods: The determination of antimicrobial susceptibility of plant extracts was done using the broth micro-dilution assay against five microorganisms. The free radical scavenging activity was determined by using DPPH (2, 2-diphenyly-1-picrylhydrazyl). Cytotoxicity activity of the plant extracts was done on Vero African monkey cells lines with 2, 3-bis [2-methoxy-4-nitro-5-sulfophenyl]-2H-tetrazolium-5-carboxanilide (XTT) reagents. Results: Our results suggest that extracts of Acacia karroo and Rhoicissus tridentata subsp. cuneifolia are potential candidates with a good antimicrobial, antioxidant and low cytotoxicity activities. This results may support the anecdotal claims for the use of the selected plant species to treat venereal diseases.
Description
Keywords
Antimicrobial, Antioxidant, Cytotoxicity, Sexually transmitted disease (STD)
Sustainable Development Goals
Citation
Tshikalange, TE, Mamba, P & Adebayo, SA 2016, 'Antimicrobial, antioxidant and cytotoxicity studies of medicinal plants used in the treatment of sexually transmitted diseases', International Journal of Pharmacognosy and Phytochemical Research, vol. 8, no. 11, pp. 1891-1895.