dc.contributor.author |
Tshikalange, Thilivhali Emmanuel
|
|
dc.contributor.author |
Mamba, P.
|
|
dc.contributor.author |
Adebayo, Salmon A.
|
|
dc.date.accessioned |
2017-05-15T08:34:06Z |
|
dc.date.available |
2017-05-15T08:34:06Z |
|
dc.date.issued |
2016-11-15 |
|
dc.description.abstract |
CONTEXT : The World Health Organization reported that more than 1 million sexually transmitted infections (STIs) are acquired daily, with an estimated 357 million new infections caused by either chlamydia, gonorrhoea, syphilis or trichomoniasis. Aim: The present study was aimed to evaluate antimicrobial, antioxidant and cytotoxicity activities of ethanol extracts of ten ethnobotanical selected plant species used to treat STD’s and related symptoms. Methods: The determination of antimicrobial susceptibility of plant extracts was done using the broth micro-dilution assay against five microorganisms. The free radical scavenging activity was determined by using DPPH (2, 2-diphenyly-1-picrylhydrazyl). Cytotoxicity activity of the plant extracts was done on Vero African monkey cells lines with 2, 3-bis [2-methoxy-4-nitro-5-sulfophenyl]-2H-tetrazolium-5-carboxanilide (XTT) reagents. Results: Our results suggest that extracts of Acacia karroo and Rhoicissus tridentata subsp. cuneifolia are potential candidates with a good antimicrobial, antioxidant and low cytotoxicity activities. This results may support the anecdotal claims for the use of the selected plant species to treat venereal diseases. |
en_ZA |
dc.description.department |
Plant Production and Soil Science |
en_ZA |
dc.description.librarian |
am2017 |
en_ZA |
dc.description.sponsorship |
The National Research Foundation (NRF Grant no: 99022) |
en_ZA |
dc.description.uri |
http://www.ijppr.com/ |
en_ZA |
dc.identifier.citation |
Tshikalange, TE, Mamba, P & Adebayo, SA 2016, 'Antimicrobial, antioxidant and cytotoxicity studies of medicinal plants used in the treatment of sexually transmitted diseases', International Journal of Pharmacognosy and Phytochemical Research, vol. 8, no. 11, pp. 1891-1895. |
en_ZA |
dc.identifier.issn |
0975-4873 |
|
dc.identifier.uri |
http://hdl.handle.net/2263/60451 |
|
dc.language.iso |
en |
en_ZA |
dc.publisher |
INDIA Publishers |
en_ZA |
dc.rights |
INDIA Publishers |
en_ZA |
dc.subject |
Antimicrobial |
en_ZA |
dc.subject |
Antioxidant |
en_ZA |
dc.subject |
Cytotoxicity |
en_ZA |
dc.subject |
Sexually transmitted disease (STD) |
en_ZA |
dc.title |
Antimicrobial, antioxidant and cytotoxicity studies of medicinal plants used in the treatment of sexually transmitted diseases |
en_ZA |
dc.type |
Article |
en_ZA |