dc.contributor.author |
Mazur, Natalie I.
|
|
dc.contributor.author |
Bont, Louis
|
|
dc.contributor.author |
Cohen, Adam L.
|
|
dc.contributor.author |
Cohen, Cheryl
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|
dc.contributor.author |
Von Gottberg, Anne
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|
dc.contributor.author |
Groome, Michelle J.
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|
dc.contributor.author |
Hellferscee, Orienka
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|
dc.contributor.author |
Klipstein-Grobusch, Kerstin
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|
dc.contributor.author |
Mekgoe, Omphile Tschegofatso
|
|
dc.contributor.author |
Naby, Fathima
|
|
dc.contributor.author |
Moyes, Jocelyn
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|
dc.contributor.author |
Tempia, Stefano
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dc.contributor.author |
Treurnicht, Florette K.
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|
dc.contributor.author |
Venter, Marietjie
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dc.contributor.author |
Walaza, Sibongile
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dc.contributor.author |
Wolter, Nicole
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dc.contributor.author |
Madhi, Shabir A.
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|
dc.date.accessioned |
2017-05-02T09:26:16Z |
|
dc.date.issued |
2017-02 |
|
dc.description.abstract |
BACKGROUND : Molecular diagnostics enable sensitive detection of respiratory viruses, but their clinical significance remains unclear in pediatric lower respiratory tract infection (LRTI). We aimed to determine whether viral coinfections increased life-threatening disease in a large cohort. METHODS : Molecular testing was performed for respiratory viruses in nasopharyngeal aspirates collected from children aged <5 years within 24 hours of hospital admission during sentinel surveillance for severe acute respiratory illness (SARI) hospitalization conducted in South Africa during February 2009–December 2013. The primary outcome was life-threatening disease, defined as mechanical ventilation, intensive care unit admission, or death. RESULTS : Of 2322 HIV-uninfected children with respiratory syncytial virus (RSV)–associated LRTI, 1330 (57.3%) had RSV monoinfection, 38 (1.6%) had life-threatening disease, 575 (24.8%) had rhinovirus, 347 (14.9%) had adenovirus (ADV), and 30 (1.3%) had influenza virus. RSV and any other viral coinfection was not associated with severe disease (odds ratio [OR], 1.4; 95% confidence interval [CI], OR, 0.74; 95% CI, .39–1.4), ADV coinfection had increased odds of life-threatening disease (adjusted OR,
3.4; 95% CI, 1.6–7.2; P = .001), and influenza coinfection had increased odds of life-threatening disease and prolonged length of stay
(adjusted OR, 2.1; 95% CI, 1.0–4.5; P = .05) compared with RSV monoinfection.
CONCLUSIONS : RSV coinfection with any respiratory virus is not associated with more severe disease when compared to RSV
alone in this study. However, increased life-threatening disease in RSV-ADV and RSV-influenza coinfection warrants further study |
en_ZA |
dc.description.department |
Medical Virology |
en_ZA |
dc.description.embargo |
2018-02-28 |
|
dc.description.librarian |
hb2017 |
en_ZA |
dc.description.uri |
http://cid.oxfordjournals.org |
en_ZA |
dc.identifier.citation |
Mazur, NI, Bont, L, Cohen, AL, Cohen, C, Von Gottberg, A, Groome, MJ, Hellferscee, O, Klipstein-Grobusch, K, Mekgoe, O, Naby, F, Moyes, J, Tempia, S, Treurnicht, FK, Venter, M, Walaza, S, Wolter, N & Madhi, SA 2017, 'Severity of respiratory syncytial virus lower respiratory tract infection with viral coinfection in HIV-uninfected children', Clinical Infectious Diseases, vol. 64, no. 4, pp. 443-450. |
en_ZA |
dc.identifier.issn |
1058-4838 (print) |
|
dc.identifier.issn |
1537-6591 (online) |
|
dc.identifier.other |
10.1093/cid/ciw756 |
|
dc.identifier.uri |
http://hdl.handle.net/2263/60148 |
|
dc.language.iso |
en |
en_ZA |
dc.publisher |
Oxford University Press |
en_ZA |
dc.rights |
© The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. . This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Clinical Infectious Diseases following peer review. The definitive publisher-authenticated version is : Severity of respiratory syncytial virus lower respiratory tract infection with viral coinfection in HIV-uninfected children, in Clinical Infectious Diseases, vol. 64, no. 4, pp. 443-450, 2017. doi : 10.1093/cid/ciw756, is available online at : http://cid.oxfordjournals.org. |
en_ZA |
dc.subject |
Respiratory syncytial virus (RSV) |
en_ZA |
dc.subject |
Viral coinfection |
en_ZA |
dc.subject |
Lower respiratory tract infection (LRTI) |
en_ZA |
dc.title |
Severity of respiratory syncytial virus lower respiratory tract infection with viral coinfection in HIV-uninfected children |
en_ZA |
dc.type |
Postprint Article |
en_ZA |