Lipidome determinants of maximal lifespan in mammals

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Authors

Bozek, Katarzyna
Khrameeva, Ekaterina E.
Reznick, Jane
Omerbasic, Damir
Bennett, Nigel Charles
Lewin, Gary R.
Azpurua, Jorge
Gorbunova, Vera
Seluanov, Andrei
Regnard, Pierrick

Journal Title

Journal ISSN

Volume Title

Publisher

Nature Publishing Group

Abstract

Maximal lifespan of mammalian species, even if closely related, may differ more than 10-fold, however the nature of the mechanisms that determine this variability is unresolved. Here, we assess the relationship between maximal lifespan duration and concentrations of more than 20,000 lipid compounds, measured in 669 tissue samples from 6 tissues of 35 species representing three mammalian clades: primates, rodents and bats. We identify lipids associated with species’ longevity across the three clades, uncoupled from other parameters, such as basal metabolic rate, body size, or body temperature. These lipids clustered in specific lipid classes and pathways, and enzymes linked to them display signatures of greater stabilizing selection in long-living species, and cluster in functional groups related to signaling and protein-modification processes. These findings point towards the existence of defined molecular mechanisms underlying variation in maximal lifespan among mammals.

Description

Keywords

Mammals, Lifespan, Lipids, Longevity

Sustainable Development Goals

Citation

Bozek, k, Khrameeva, EE, Reznick, J, Omerbasic, D, Bennett, NC, Lewin, GR, Azpurua, J, Gorbunova, V, Seluanov, A, Regnard, P, Wanert, F, Marchal, J, Pifferi, F, Aujard, F, Liu, Z, Shi, P, Paabo, S, Schroeder, F, Willmitzer, L, Giavalisco, P & Khaitovich, P 2017, 'Lipidome determinants of maximal lifespan in mammals', Scientific Reports, vol. 7, no. 5, pp. 1-10.