Lipidome determinants of maximal lifespan in mammals
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Date
Authors
Bozek, Katarzyna
Khrameeva, Ekaterina E.
Reznick, Jane
Omerbasic, Damir
Bennett, Nigel Charles
Lewin, Gary R.
Azpurua, Jorge
Gorbunova, Vera
Seluanov, Andrei
Regnard, Pierrick
Journal Title
Journal ISSN
Volume Title
Publisher
Nature Publishing Group
Abstract
Maximal lifespan of mammalian species, even if closely related, may differ more than 10-fold,
however the nature of the mechanisms that determine this variability is unresolved. Here, we assess
the relationship between maximal lifespan duration and concentrations of more than 20,000 lipid
compounds, measured in 669 tissue samples from 6 tissues of 35 species representing three mammalian
clades: primates, rodents and bats. We identify lipids associated with species’ longevity across the
three clades, uncoupled from other parameters, such as basal metabolic rate, body size, or body
temperature. These lipids clustered in specific lipid classes and pathways, and enzymes linked to them
display signatures of greater stabilizing selection in long-living species, and cluster in functional groups
related to signaling and protein-modification processes. These findings point towards the existence of
defined molecular mechanisms underlying variation in maximal lifespan among mammals.
Description
Keywords
Mammals, Lifespan, Lipids, Longevity
Sustainable Development Goals
Citation
Bozek, k, Khrameeva, EE, Reznick, J, Omerbasic, D, Bennett, NC, Lewin, GR, Azpurua, J, Gorbunova, V, Seluanov, A, Regnard, P, Wanert, F, Marchal, J, Pifferi, F, Aujard, F, Liu, Z, Shi, P, Paabo, S, Schroeder, F, Willmitzer, L, Giavalisco, P & Khaitovich, P 2017, 'Lipidome determinants of maximal lifespan in mammals', Scientific Reports, vol. 7, no. 5, pp. 1-10.