Lipidome determinants of maximal lifespan in mammals

Show simple item record Bozek, Katarzyna Khrameeva, Ekaterina E. Reznick, Jane Omerbasic, Damir Bennett, Nigel Charles Lewin, Gary R. Azpurua, Jorge Gorbunova, Vera Seluanov, Andrei Regnard, Pierrick Wanert, Fanelie Marchal, Julia Pifferi, Fabien Aujard, Fabienne Liu, Zhen Shi, Peng Paabo, Svante Schroeder, Florian Willmitzer, Lothar Giavalisco, Patrick Khaitovich, Philipp 2017-04-20T17:14:59Z 2017-04-20T17:14:59Z 2017-01-31
dc.description.abstract Maximal lifespan of mammalian species, even if closely related, may differ more than 10-fold, however the nature of the mechanisms that determine this variability is unresolved. Here, we assess the relationship between maximal lifespan duration and concentrations of more than 20,000 lipid compounds, measured in 669 tissue samples from 6 tissues of 35 species representing three mammalian clades: primates, rodents and bats. We identify lipids associated with species’ longevity across the three clades, uncoupled from other parameters, such as basal metabolic rate, body size, or body temperature. These lipids clustered in specific lipid classes and pathways, and enzymes linked to them display signatures of greater stabilizing selection in long-living species, and cluster in functional groups related to signaling and protein-modification processes. These findings point towards the existence of defined molecular mechanisms underlying variation in maximal lifespan among mammals. en_ZA
dc.description.department Zoology and Entomology en_ZA
dc.description.librarian am2017 en_ZA
dc.description.sponsorship The National Natural Science Foundation of China (grant 31420103920), Strategic Priority Research Program of the Chinese Academy of Sciences (grant XDB13010200), the National Natural Science Foundation of China (grant 91331203), the National One Thousand Foreign Experts Plan (grant WQ20123100078), the Bureau of International Cooperation, Chinese Academy of Sciences (grant GJHZ201313) and the Federal Targeted Program for Research and Development in Priority Areas of Advancement of the Russian Scientific and Technological Complex for 2014–2020 (the Ministry of Education and Science of the Russian Federation), grant № 14.615.21.0002, the Unique identifier of the agreement: RFMEFI61515×0002. Additional support was obtained from the European Research Council (advanced grant 294678 to GRL). en_ZA
dc.description.uri en_ZA
dc.identifier.citation Bozek, k, Khrameeva, EE, Reznick, J, Omerbasic, D, Bennett, NC, Lewin, GR, Azpurua, J, Gorbunova, V, Seluanov, A, Regnard, P, Wanert, F, Marchal, J, Pifferi, F, Aujard, F, Liu, Z, Shi, P, Paabo, S, Schroeder, F, Willmitzer, L, Giavalisco, P & Khaitovich, P 2017, 'Lipidome determinants of maximal lifespan in mammals', Scientific Reports, vol. 7, no. 5, pp. 1-10. en_ZA
dc.identifier.issn 2045-2322 (online)
dc.identifier.other 10.1038/s41598-017-00037-7
dc.language.iso en en_ZA
dc.publisher Nature Publishing Group en_ZA
dc.rights © The Author(s) 2017. This work is licensed under a Creative Commons Attribution 4.0 International License. en_ZA
dc.subject Mammals en_ZA
dc.subject Lifespan en_ZA
dc.subject Lipids en_ZA
dc.subject Longevity en_ZA
dc.title Lipidome determinants of maximal lifespan in mammals en_ZA
dc.type Article en_ZA

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