Comparison of the therapeutic dose of warfarin in HIV-infected and HIV-uninfected patients : a study of clinical practice

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dc.contributor.author Jackson, B.S.
dc.contributor.author Mokoena, Taole
dc.date.accessioned 2017-03-10T07:15:19Z
dc.date.available 2017-03-10T07:15:19Z
dc.date.issued 2017
dc.description.abstract BACKGROUND : People infected with HIV are prone to venous thrombosis. Treatment of thrombosis is primarily with warfarin. No studies have addressed the effects of HIV infection on warfarin dose. The aims of this study were to determine whether the therapeutic dose of warfarin and induction time to therapeutic dose in HIV-infected patients differ from that in HIV-uninfected patients. METHODS : A prospective and retrospective descriptive study of induction time to therapeutic warfarin dose, as well as of ambulant therapeutic warfarin dose, was performed. HIV-infected and HIV-uninfected patients being treated after deep venous thrombosis with or without pulmonary embolism were compared. Sex and use of antiretroviral drugs (ARVs) were also compared in the groups. RESULTS : 234 patients were entered into the study. Induction time to therapeutic warfarin dose did not differ between the 2 groups. The mean therapeutic dose of warfarin was higher in the HIV-infected than the HIV-uninfected group: 6.06 vs 5.72 mg/day, but this was not statistically significant ( p=0.29). There was no difference in therapeutic warfarin dose between ARV-naïve groups—HIV-uninfected and HIV-infected patients not on ARVs. CONCLUSIONS : There appears to be little effect of HIV infection on warfarin dosing. Warfarin therapy should be administered conventionally in HIV-infected patients. en_ZA
dc.description.department Surgery en_ZA
dc.description.librarian am2017 en_ZA
dc.description.uri http://bmjopen.bmj.com en_ZA
dc.identifier.citation Jackson BS, Mokoena T. Comparison of the therapeutic dose of warfarin in HIVinfected and HIV-uninfected patients: a study of clinical practice. BMJ Open 2017;7:e013709. DOI: 10.1136/bmjopen-2016-013709. en_ZA
dc.identifier.issn 2044-6055
dc.identifier.other 10.1136/bmjopen-2016-013709
dc.identifier.uri http://hdl.handle.net/2263/59370
dc.language.iso en en_ZA
dc.publisher BMJ Publishing Group en_ZA
dc.rights This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license. en_ZA
dc.subject Patients en_ZA
dc.subject HIV-infected en_ZA
dc.subject HIV-uninfected en_ZA
dc.subject Human immunodeficiency virus (HIV) en_ZA
dc.subject Antiretroviral (ARV) en_ZA
dc.subject Venous thrombosis en_ZA
dc.title Comparison of the therapeutic dose of warfarin in HIV-infected and HIV-uninfected patients : a study of clinical practice en_ZA
dc.type Article en_ZA


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