Interrelation between inflammation, thrombosis, and neuroprotection in cerebral ischemia

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dc.contributor.author Van der Spuy, Wendy Jeannette
dc.contributor.author Pretorius, Etheresia
dc.date.accessioned 2017-03-06T06:42:32Z
dc.date.available 2017-03-06T06:42:32Z
dc.date.issued 2012-05
dc.description.abstract Stroke by mechanism of thrombotic cerebral ischemia is one of the leading causes of death and/or disability worldwide. Current research is under consensus that there are sex-based differences in both the prevalence and presentation of stroke and thrombosis. Here we discuss the interrelation between thrombosis and inflammation and call attention to points in the cerebral ischemic cascade where estrogen may be involved in neuroprotection. Cerebral ischemia triggers a series of events including inflammation, which is deeply interrelated with thrombosis; inflammation not only produces local thrombosis, but thrombosis can also amplify inflammation especially through the synergism of leukocyte and platelet activity. Research involving experimental animal models of cerebral ischemia has shown that sex hormones, especially estrogen, offer a degree of neuroprotection. Mechanisms of this neuroprotection may be linked to certain anti-inflammatory properties of estrogen, as well as estrogen ’ s regulation of thrombosis through the lowering of coagulation factors, among others. It is also understood that sex hormones alter the function and morphology of platelets and fibrin networks, and changes in platelet and fibrin network morphology offer one of the earliest confirmations of inflammation. Sex hormone levels, inflammatory processes, and thrombotic mechanisms are profoundly interconnected in predicting the outcome of cerebral ischemia. en_ZA
dc.description.department Anatomy en_ZA
dc.description.department Physiology en_ZA
dc.description.librarian am2017 en_ZA
dc.description.uri http://www.degruyter.comview/j/revneuro en_ZA
dc.identifier.citation Van der Spuy, WJ & Pretorius, E 2012, 'Interrelation between inflammation, thrombosis, and neuroprotection in cerebral ischemia', Reviews in the Neurosciences, vol. 23, no.3, pp. 269-278. en_ZA
dc.identifier.issn 0334-1763 (print)
dc.identifier.issn 2191-0200 (online)
dc.identifier.other 10.1515/revneuro-2012-0028
dc.identifier.uri http://hdl.handle.net/2263/59264
dc.language.iso en en_ZA
dc.publisher De Gruyter en_ZA
dc.rights © 2012 Walter de Gruyter en_ZA
dc.subject Anti-inflammatory en_ZA
dc.subject Coagulation en_ZA
dc.subject Estrogen en_ZA
dc.subject Leukocytes en_ZA
dc.subject Platelets en_ZA
dc.title Interrelation between inflammation, thrombosis, and neuroprotection in cerebral ischemia en_ZA
dc.type Article en_ZA


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