Crosstalk between the microbiome and cancer cells by quorum sensing peptides

Show simple item record Wynendaele, Evelien Verbeke, Frederick D’Hondt, Matthias Hendrix, An Van de Wiele, Christophe Burvenich, Christian Peremans, Kathelijne De Wever, Olivier Bracke, Marc De Spiegeleer, Bart 2017-03-03T05:18:38Z 2017-03-03T05:18:38Z 2015-02
dc.description.abstract To date, the precise role of the human microbiome in health and disease states remains largely undefined. Complex and selective crosstalk systems between the microbiome and mammalian cells are also not yet reported. Research up till now mainly focused on bacterial synthesis of virulence factors, reactive oxygen/nitrogen species (ROS/RNS) and hydrogen sulphide, as well as on the activation of exogenous mutagen precursors by intestinal bacteria. We discovered that certain quorum sensing peptides, produced by bacteria, interact with mammalian cells, in casu cancer cells: Phr0662 (Bacillus sp.), EntF-metabolite (Enterococcus faecium) and EDF-derived (Escherichia coli) peptides initiate HCT-8/E11 colon cancer cell invasion, with Phr0662 also promoting angiogenesis. Our findings thus indicate that the human microbiome, through their quorum sensing peptides, may be one of the factors responsible for cancer metastasis. en_ZA
dc.description.department Nuclear Medicine en_ZA
dc.description.librarian hb2017 en_ZA
dc.description.sponsorship This work was supported by the Special Research Fund of Ghent University [Grant number BOF 01J22510 to B.D.S. and E.W.] and the Institute for the Promotion of Innovation through Science and Technology in Flanders (IWT-Vlaanderen) [Grant numbers 131356 to F.V. and 101529 to M.D.]. en_ZA
dc.identifier.citation Wynendaele, E, Verbeke, F, D’Hondt, M, Hendrix, A, Van de Wiele, C, Burvenich, C, Peremans, K, De Wever, O, Bracke, M & De Spiegeleer, B 2015, 'Crosstalk between the microbiome and cancer cells by quorum sensing peptides', Peptides, vol. 64, pp. 40-48. en_ZA
dc.identifier.issn 0196-9781 (print)
dc.identifier.issn 1873-5169 (online)
dc.identifier.other 10.1016/j.peptides.2014.12.009
dc.language.iso en en_ZA
dc.publisher Elsevier en_ZA
dc.rights © 2014 Elsevier Inc. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Peptides. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. A definitive version was subsequently published in Peptides, vol. 64, pp. 40-48, 2015. doi : 10.1016/j.peptides.2014.12.009. en_ZA
dc.subject Quorum sensing peptides en_ZA
dc.subject Colon cancer en_ZA
dc.subject Metastasis en_ZA
dc.subject Microbiome en_ZA
dc.subject Angiogenesis en_ZA
dc.title Crosstalk between the microbiome and cancer cells by quorum sensing peptides en_ZA
dc.type Postprint Article en_ZA

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