Crosstalk between the microbiome and cancer cells by quorum sensing peptides

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Authors

Wynendaele, Evelien
Verbeke, Frederick
D’Hondt, Matthias
Hendrix, An
Van de Wiele, Christophe
Burvenich, Christian
Peremans, Kathelijne
De Wever, Olivier
Bracke, Marc
De Spiegeleer, Bart

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Volume Title

Publisher

Elsevier

Abstract

To date, the precise role of the human microbiome in health and disease states remains largely undefined. Complex and selective crosstalk systems between the microbiome and mammalian cells are also not yet reported. Research up till now mainly focused on bacterial synthesis of virulence factors, reactive oxygen/nitrogen species (ROS/RNS) and hydrogen sulphide, as well as on the activation of exogenous mutagen precursors by intestinal bacteria. We discovered that certain quorum sensing peptides, produced by bacteria, interact with mammalian cells, in casu cancer cells: Phr0662 (Bacillus sp.), EntF-metabolite (Enterococcus faecium) and EDF-derived (Escherichia coli) peptides initiate HCT-8/E11 colon cancer cell invasion, with Phr0662 also promoting angiogenesis. Our findings thus indicate that the human microbiome, through their quorum sensing peptides, may be one of the factors responsible for cancer metastasis.

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Keywords

Quorum sensing peptides, Colon cancer, Metastasis, Microbiome, Angiogenesis

Sustainable Development Goals

Citation

Wynendaele, E, Verbeke, F, D’Hondt, M, Hendrix, A, Van de Wiele, C, Burvenich, C, Peremans, K, De Wever, O, Bracke, M & De Spiegeleer, B 2015, 'Crosstalk between the microbiome and cancer cells by quorum sensing peptides', Peptides, vol. 64, pp. 40-48.