dc.contributor.author |
Wynendaele, Evelien
|
|
dc.contributor.author |
Verbeke, Frederick
|
|
dc.contributor.author |
D’Hondt, Matthias
|
|
dc.contributor.author |
Hendrix, An
|
|
dc.contributor.author |
Van de Wiele, Christophe
|
|
dc.contributor.author |
Burvenich, Christian
|
|
dc.contributor.author |
Peremans, Kathelijne
|
|
dc.contributor.author |
De Wever, Olivier
|
|
dc.contributor.author |
Bracke, Marc
|
|
dc.contributor.author |
De Spiegeleer, Bart
|
|
dc.date.accessioned |
2017-03-03T05:18:38Z |
|
dc.date.available |
2017-03-03T05:18:38Z |
|
dc.date.issued |
2015-02 |
|
dc.description.abstract |
To date, the precise role of the human microbiome in health and disease states remains largely
undefined. Complex and selective crosstalk systems between the microbiome and mammalian
cells are also not yet reported. Research up till now mainly focused on bacterial synthesis of
virulence factors, reactive oxygen/nitrogen species (ROS/RNS) and hydrogen sulphide, as well as
on the activation of exogenous mutagen precursors by intestinal bacteria. We discovered that
certain quorum sensing peptides, produced by bacteria, interact with mammalian cells, in casu
cancer cells: Phr0662 (Bacillus sp.), EntF-metabolite (Enterococcus faecium) and EDF-derived
(Escherichia coli) peptides initiate HCT-8/E11 colon cancer cell invasion, with Phr0662 also
promoting angiogenesis. Our findings thus indicate that the human microbiome, through their
quorum sensing peptides, may be one of the factors responsible for cancer metastasis. |
en_ZA |
dc.description.department |
Nuclear Medicine |
en_ZA |
dc.description.librarian |
hb2017 |
en_ZA |
dc.description.sponsorship |
This work was supported by the Special Research Fund of Ghent
University [Grant number BOF 01J22510 to B.D.S. and E.W.] and the Institute for the Promotion
of Innovation through Science and Technology in Flanders (IWT-Vlaanderen) [Grant numbers
131356 to F.V. and 101529 to M.D.]. |
en_ZA |
dc.identifier.citation |
Wynendaele, E, Verbeke, F, D’Hondt, M, Hendrix, A, Van de Wiele, C, Burvenich, C, Peremans, K, De Wever, O, Bracke, M & De Spiegeleer, B 2015, 'Crosstalk between the microbiome and cancer cells by quorum sensing peptides', Peptides, vol. 64, pp. 40-48. |
en_ZA |
dc.identifier.issn |
0196-9781 (print) |
|
dc.identifier.issn |
1873-5169 (online) |
|
dc.identifier.other |
10.1016/j.peptides.2014.12.009 |
|
dc.identifier.uri |
http://hdl.handle.net/2263/59248 |
|
dc.language.iso |
en |
en_ZA |
dc.publisher |
Elsevier |
en_ZA |
dc.rights |
© 2014 Elsevier Inc. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Peptides. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. A definitive version was subsequently published in Peptides, vol. 64, pp. 40-48, 2015. doi : 10.1016/j.peptides.2014.12.009. |
en_ZA |
dc.subject |
Quorum sensing peptides |
en_ZA |
dc.subject |
Colon cancer |
en_ZA |
dc.subject |
Metastasis |
en_ZA |
dc.subject |
Microbiome |
en_ZA |
dc.subject |
Angiogenesis |
en_ZA |
dc.title |
Crosstalk between the microbiome and cancer cells by quorum sensing peptides |
en_ZA |
dc.type |
Postprint Article |
en_ZA |