The effect of the resistive properties of bone on neural excitation and electric fields in cochlear implant models

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dc.contributor.author Malherbe, Tiaan Krynauw
dc.contributor.author Hanekom, Tania
dc.contributor.author Hanekom, J.J. (Johannes Jurgens)
dc.date.accessioned 2017-03-02T12:18:20Z
dc.date.available 2017-03-02T12:18:20Z
dc.date.issued 2015-09
dc.description.abstract The resistivity of bone is the most variable of all the tissues in the human body, ranging from 312 U cm to 84,745 U cm. Volume conduction models of cochlear implants have generally used a resistivity value of 641 U cm for the bone surrounding the cochlea. This study investigated the effect that bone resistivity has on modelled neural thresholds and intracochlear potentials using user-specific volume conduction models of implanted cochleae applying monopolar stimulation. The complexity of the description of the head volume enveloping the cochlea was varied between a simple infinite bone volume and a detailed skull containing a brain volume, scalp and accurate return electrode position. It was found that, depending on the structure of the head model and implementation of the return electrode, different bone resistivity values are necessary to match model predictions to data from literature. Modelled forward-masked spatial tuning curve (fmSTC) widths and slopes and intracochlear electric field profile length constants were obtained for a range of bone resistivity values for the various head models. The predictions were compared to measurements found in literature. It was concluded that, depending on the head model, a bone resistivity value between 3500 U cm and 10,500 U cm allows prediction of neural and electrical responses that match measured data. A general recommendation is made to use a resistivity value of approximately 10,000 U cm for bone volumes in conduction models of the implanted cochlea when neural excitation is predicted and a value of approximately 6500 U cm when predicting electric fields inside the cochlear duct. en_ZA
dc.description.department Electrical, Electronic and Computer Engineering en_ZA
dc.description.librarian hb2017 en_ZA
dc.description.sponsorship The National Research Foundation (South Africa) en_ZA
dc.description.uri http://www.elsevier.com/locate/heares en_ZA
dc.identifier.citation Malherbe, TK, Hanekom, T & Hanekom, JJ 2015, 'The effect of the resistive properties of bone on neural excitation and electric fields in cochlear implant models', Hearing Research, vol. 327, pp. 126-135. en_ZA
dc.identifier.issn 0378-5955 (print)
dc.identifier.issn 1878-5891 (online)
dc.identifier.other 10.1016/j.heares.2015.06.003
dc.identifier.uri http://hdl.handle.net/2263/59237
dc.language.iso en en_ZA
dc.publisher Elsevier en_ZA
dc.rights © 2015 Elsevier B.V. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Hearing Research. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. A definitive version was subsequently published in Hearing Research, vol. 327, pp. 126-135, 2015. doi : 10.1016/j.heares.2015.06.003. en_ZA
dc.subject Cochlear implant en_ZA
dc.subject Volume conduction model en_ZA
dc.subject Bone resistivity en_ZA
dc.subject Neural excitation en_ZA
dc.subject Subject specific en_ZA
dc.subject Intracochlear potentials en_ZA
dc.subject Skull model en_ZA
dc.subject Forward-masked spatial tuning curve (fmSTC) en_ZA
dc.subject Volume conduction (VC) en_ZA
dc.subject Electrical field imaging (EFI) en_ZA
dc.subject Finite element method (FEM) en_ZA
dc.title The effect of the resistive properties of bone on neural excitation and electric fields in cochlear implant models en_ZA
dc.type Postprint Article en_ZA


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