Objective measures of function of the peripheral auditory system in adults with diabetes mellitus type 1 and type 2 : a systematic review and meta-analysis

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dc.contributor.advisor Vinck, Bart M.
dc.contributor.coadvisor Heinze, Barbara M.
dc.contributor.postgraduate Köstlin, Nicole
dc.date.accessioned 2017-02-24T08:01:29Z
dc.date.available 2017-02-24T08:01:29Z
dc.date.created 2017-01-24
dc.date.issued 2016
dc.description Dissertation (MA)--University of Pretoria, 2016. en_ZA
dc.description.abstract Objective: This study aimed to systematically review and analyse the available peer-reviewed literature reporting on the results of distortion product otoacoustic emissions (DPOAEs), transient evoked otoacoustic emissions (TEOAEs) and click auditory brainstem responses (c-ABRs) in adults with type 1 and type 2 diabetes mellitus (T1DM and T2DM). Method: A comprehensive literature search was conducted across three electronic databases to identify English; peer-reviewed articles that included results of OAEs (DPOAEs and TEOAEs) and c-ABR tests in adult subjects with DM. Articles were selected according to predetermined selection criteria and critically reviewed independently by two researchers. Results: 15 studies met the inclusion criteria for the systematic review while nine articles qualified for inclusion in the meta-analysis. DPOAE studies reported significantly reduced amplitudes with only one study reporting larger amplitudes. Abnormal TEOAEs were reported in all TEOAE studies, although these abnormalities were not always significant. Significantly delayed c-ABRs were reported in all ABR studies. Analysis of c-ABR mean wave latencies identified longer latencies for DM subjects, particularly for wave III and V, as well as for IPL I-III and I-V. Conclusions: Subjects with T1DM and T2DM may present with clinical or subclinical impairment of the cochlear outer hair cells and both the peripheral and central auditory pathway. en_ZA
dc.description.availability Unrestricted en_ZA
dc.description.degree MA en_ZA
dc.description.department Speech-Language Pathology and Audiology en_ZA
dc.identifier.citation Köstlin, N 2016, Objective measures of function of the peripheral auditory system in adults with diabetes mellitus type 1 and type 2 : a systematic review and meta-analysis, MA Dissertation, University of Pretoria, Pretoria, viewed yymmdd <http://hdl.handle.net/2263/59163>
dc.identifier.other A2017
dc.identifier.uri http://hdl.handle.net/2263/59163
dc.publisher University of Pretoria
dc.rights © 2017 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. en_ZA
dc.subject Audiology en_ZA
dc.subject UCTD
dc.subject Diabetes mellitus
dc.subject Hearing loss
dc.subject Auditory nerve
dc.subject Auditory brainstem responses
dc.subject Distortion product otoacoustic emissions
dc.title Objective measures of function of the peripheral auditory system in adults with diabetes mellitus type 1 and type 2 : a systematic review and meta-analysis en_ZA
dc.type Dissertation en_ZA


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