Objective measures of function of the peripheral auditory system in adults with diabetes mellitus type 1 and type 2 : a systematic review and meta-analysis
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University of Pretoria
Abstract
Objective: This study aimed to systematically review and analyse the available peer-reviewed literature reporting on the results of distortion product otoacoustic emissions (DPOAEs), transient evoked otoacoustic emissions (TEOAEs) and click auditory brainstem responses (c-ABRs) in adults with type 1 and type 2 diabetes mellitus (T1DM and T2DM).
Method: A comprehensive literature search was conducted across three electronic databases to identify English; peer-reviewed articles that included results of OAEs (DPOAEs and TEOAEs) and c-ABR tests in adult subjects with DM. Articles were selected according to predetermined selection criteria and critically reviewed independently by two researchers.
Results: 15 studies met the inclusion criteria for the systematic review while nine articles qualified for inclusion in the meta-analysis. DPOAE studies reported significantly reduced amplitudes with only one study reporting larger amplitudes. Abnormal TEOAEs were reported in all TEOAE studies, although these abnormalities were not always significant. Significantly delayed c-ABRs were reported in all ABR studies. Analysis of c-ABR mean wave latencies identified longer latencies for DM subjects, particularly for wave III and V, as well as for IPL I-III and I-V.
Conclusions: Subjects with T1DM and T2DM may present with clinical or subclinical impairment of the cochlear outer hair cells and both the peripheral and central auditory pathway.
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Dissertation (MA)--University of Pretoria, 2016.
Keywords
Audiology, UCTD, Diabetes mellitus, Hearing loss, Auditory nerve, Auditory brainstem responses, Distortion product otoacoustic emissions
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Köstlin, N 2016, Objective measures of function of the peripheral auditory system in adults with diabetes mellitus type 1 and type 2 : a systematic review and meta-analysis, MA Dissertation, University of Pretoria, Pretoria, viewed yymmdd <http://hdl.handle.net/2263/59163>