Maternal serum levels of perfluoroalkyl substances and organochlorines and indices of fetal growth : a Scandinavian case–cohort study

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dc.contributor.author Lauritzen, Hilde B.
dc.contributor.author Larose, Tricia L.
dc.contributor.author Oien, Torbjorn
dc.contributor.author Sandanger, Torkjel M.
dc.contributor.author Odland, Jon Oyvind
dc.contributor.author Van de Bor, Margot
dc.contributor.author Jacobsen, Geir W.
dc.date.accessioned 2017-02-09T09:25:01Z
dc.date.available 2017-02-09T09:25:01Z
dc.date.issued 2017-01
dc.description.abstract BACKGROUND : The associations between prenatal exposure to endocrine disruptive chemicals (EDCs) and fetal growth are inconsistent, and few studies have considered small-for-gestational- age (SGA) birth as an outcome. Our current study of Scandinavian parous women aimed to address these inconsistencies and gaps in the literature. METHODS : This case–cohort study included 424 mother– child pairs who participated in a prospective, multi-center study of parous women in Norway (Trondheim and Bergen) and Sweden (Uppsala). We used linear and logistic regression with 95% confidence intervals (CIs) to analyze the associations between two perfluoroalkyl substances (PFASs) and five organochlorines (OCs) from early second trimester and indices of fetal growth. RESULTS : Among Swedish women, prenatal exposure to perfluorooctanoate (PFOA), polychlorinated biphenyl (PCB) 153 and hexachlorobenzene (HCB) were associated with higher odds for SGA birth. We found stronger associations among Swedish male offspring. In the Norwegian cohort, we found no significant associations between EDC exposure and indices of fetal growth. CONCLUSIONS : Some populations may be more vulnerable to EDCs, possibly due to differences in exposure levels, exposure sources and/or modifiable lifestyle factors. Male offspring may be more vulnerable to endocrine disruption. en_ZA
dc.description.department School of Health Systems and Public Health (SHSPH) en_ZA
dc.description.librarian am2017 en_ZA
dc.description.sponsorship Grants from the Liaison Committee between the Central Norway Regional Health Authority and the Norwegian University of Science and Technology. en_ZA
dc.description.uri http://www.nature.com/pr en_ZA
dc.identifier.citation Lauritzen, HB, Larose, TL, Oien, T, Sandanger, TM, Odland, JO, Van de Bor, M & Jacobsen, GW 2017, 'Maternal serum levels of perfluoroalkyl substances and organochlorines and indices of fetal growth : a Scandinavian case–cohort study', Pediatric Research, vol. 81, no. 1, pp. 33-42. en_ZA
dc.identifier.issn 0031-3998 (print)
dc.identifier.issn 1530-0447 (online)
dc.identifier.uri http://hdl.handle.net/2263/58953
dc.language.iso en en_ZA
dc.publisher Nature Publishing Group en_ZA
dc.rights © The Author(s) (2016) This work is licensed under a Creative Commons Attribution-NonCommercial- NoDerivs 4.0 International License. en_ZA
dc.subject Prenatal exposure en_ZA
dc.subject Fetal growth en_ZA
dc.subject Birth en_ZA
dc.subject Endocrine disruptive chemicals (EDCs) en_ZA
dc.subject Small-for-gestational-age (SGA) en_ZA
dc.title Maternal serum levels of perfluoroalkyl substances and organochlorines and indices of fetal growth : a Scandinavian case–cohort study en_ZA
dc.type Article en_ZA


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