The use of egg attenuated bluetongue virus in the production of a polyvalent vaccine for sheep. A. Propagation of the virus in sheep

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dc.contributor.author Alexander, R.A.
dc.contributor.author Haig, D.A.
dc.contributor.editor Alexander, R.A.
dc.contributor.editor Clark, R.
dc.contributor.editor Sterne, M.
dc.contributor.editor Louw, J.G.
dc.contributor.editor Van der Reyden, D.
dc.contributor.editor De Kock, V.E.
dc.date.accessioned 2017-02-02T09:57:36Z
dc.date.available 2017-02-02T09:57:36Z
dc.date.created 2017
dc.date.issued 1951
dc.description The articles have been scanned in colour with a HP Scanjet 5590; 300dpi. Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format. en_ZA
dc.description.abstract (1) A brief description of Theiler's classical method of bluetongue vaccine production is given and various modifications introduced from time to time are recorded. (2) In an attempt to adapt the recognized technique to the routine mass production of a polyvalent vaccine using fully attenuated egg adapted (A) strains of virus three difficulties were encountered : (a) As a result of even a single passage through susceptible sheep the adapted (A) strains were transformed at least partially into apparently original or sheep strains (O) so that quantitative control could not be carried out in eggs. (b) During the course of change from the A to the pseudo-O phase at least some strains show a marked change in antigenic structure. (c) Since the majority of sheep infected with egg attenuated virus show no clinical reaction it is impossible to eliminate animals included by accident amongst the virus donors. In the final mixture specific antibodies in the serum of such immune sheep neutralize the virus propagated in the susceptible donors, thus making the vaccine inert. This has proved an insurmountable difficulty. (3) Though passage through sheep causes a change from the A to the pseudo-O type of virus there is no reversion to original virulence. en_ZA
dc.identifier.citation Alexander, RA & Haig, DA 1951, 'The use of egg attenuated bluetongue virus in the production of a polyvalent vaccine for sheep. A. Propagation of the virus in sheep’, Onderstepoort Journal of Veterinary Science, vol. 25, no. 1, pp. 3-15. en_ZA
dc.identifier.issn 0330-2465
dc.identifier.uri http://hdl.handle.net/2263/58839
dc.language.iso en en_ZA
dc.publisher Published by The Government Printer, Pretoria, South Africa. en_ZA
dc.rights © 1951 ARC - Onderstepoort and Faculty of Veterinary Science, University of Pretoria (original). © 2017 University of Pretoria. Dept. of Library Services (digital). en_ZA
dc.subject Veterinary medicine en_ZA
dc.subject.lcsh Veterinary medicine -- South Africa
dc.title The use of egg attenuated bluetongue virus in the production of a polyvalent vaccine for sheep. A. Propagation of the virus in sheep en_ZA
dc.type Article en_ZA


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