Primary cutaneous malignancies in the Northern Cape Province of South Africa : a retrospective histopathological review

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dc.contributor.author York, K.
dc.contributor.author Dlova, N.C.
dc.contributor.author Wright, Caradee Yael
dc.contributor.author Khumalo, N.P.
dc.contributor.author Kellett, P.E.
dc.contributor.author Kassanjee, R.
dc.contributor.author Mosam, A.
dc.date.accessioned 2017-01-30T05:06:11Z
dc.date.available 2017-01-30T05:06:11Z
dc.date.issued 2017-01
dc.description NCD and AM made substantial contributions to the conception and design of the study and revised the manuscript critically. KY drafted the manuscript and acquired and interpreted the data. NPK assisted with interpretation and presentation of the data and revised the manuscript critically for intellectual content. RK implemented statistical analyses and assisted with presentation and interpretation of the results. CYW and PEK advised during the course of the study, and CYW assisted with manuscript preparation for submission. en_ZA
dc.description The authors acknowledge the support provided by the consulting service at the department. Maureen Krige is acknowledged for editing the manuscript. en_ZA
dc.description.abstract BACKGROUND. Excessive sun exposure and a high prevalence of HIV increase skin cancer risk in South Africa (SA). OBJECTIVE. To describe the nature and extent of skin cancers presenting in the public and private health sectors of the Northern Cape Province of SA. METHODS. A retrospective analysis of histologically confirmed new primary cutaneous malignancies from 1 January 2008 to 31 December 2012 was conducted using public and private health sector databases. Types, quantity and distribution of common invasive malignancies by population group, age, gender, anatomical site and health sector were explored. One-year cumulative incidence was calculated and logistic regression models were used to analyse incidence and melanoma thickness trends. RESULTS. A total of 4 270 biopsies (13 cutaneous malignancies) were identified. The commonest was squamous cell carcinoma (SCC), followed by basal cell carcinoma, Kaposi’s sarcoma (KS), cutaneous malignant melanoma (CMM) and basosquamous carcinoma, in descending order. The odds of a white male developing SCC increased by 8% each year (odds ratio (OR) 1.08, 95% confidence interval (CI) 1.01 - 1.15; p=0.022), while the odds of a black male developing SCC and KS decreased by 9% (OR 0.91, 95% CI 0.84 - 0.99; p=0.033) and 18% (OR 0.82, 95% CI 0.70 - 0.97; p=0.022), respectively, each year. SCC and CMM were diagnosed at more advanced stages in the public than in the private healthcare sector. CMM is being detected earlier, as indicated by low-stage depth increasing by 72% annually (OR 1.72, 95% CI 1.04 - 3.01; p=0.042). CONCLUSIONS. Results suggest that reported skin cancer patterns are changing. There is a need for further research and equitable appropriation of financial resources and effort towards developing primary skin cancer prevention initiatives in SA. en_ZA
dc.description.department Geography, Geoinformatics and Meteorology en_ZA
dc.description.librarian am2017 en_ZA
dc.description.sponsorship The Department of Medicine at the University of Cape Town (UCT) supplied funding for payment of the UCT Department of Statistical Sciences for their assistance with the statistical analysis. en_ZA
dc.description.uri http://www.samj.org.za en_ZA
dc.identifier.citation York, K, Dlova, NC, Wright, CY, Khumalo, NP, Kellett, PE, Kassanjee, R & Mosam, A 2017, 'Primary cutaneous malignancies in the Northern Cape Province of South Africa : a retrospective histopathological review', South African Medical Journal, vol. 107, no. 1, pp. 83-88. en_ZA
dc.identifier.issn 0256-9574 (print)
dc.identifier.issn 2078-5135 (online)
dc.identifier.other 10.7196/SAMJ.2017.v107i1.10924
dc.identifier.uri http://hdl.handle.net/2263/58662
dc.language.iso en en_ZA
dc.publisher Health and Medical Publishing Group en_ZA
dc.rights © 2017 Health & Medical Publishing Group. This article is licensed under a Creative Commons Attribution-NonCommercial Works License (CC BY-NC 3.0). en_ZA
dc.subject Skin cancer en_ZA
dc.subject Prevention en_ZA
dc.subject Human immunodeficiency virus (HIV) en_ZA
dc.subject South Africa (SA) en_ZA
dc.subject Excessive sun exposure en_ZA
dc.subject Northern Cape Province, South Africa en_ZA
dc.title Primary cutaneous malignancies in the Northern Cape Province of South Africa : a retrospective histopathological review en_ZA
dc.type Article en_ZA


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