The syntheses of the naturally occurring indolizidine alkaloid (±)-tashiromine and its unnatural epimer (±)-epitashiromine are
demonstrated through the use of enaminone chemistry. The impact of various electron-withdrawing substituents at the C-8 position
of the indolizidine core on the preparation of the bicyclic system is described.
Supporting Information File 1
Experimental procedures and copies of NMR spectra.