Abstract:
Antimicrobial potential of medicinal plants have been explored
extensively these days. This study was carried out to evaluate the
antibacterial potential from aerial parts of plant, called ‘Annona
senegalensis’ and its constituents. Bioassay guided fractionation led
to the isolation of four metabolites, (+)-catechin (1), (−)-anonaine (2),
(−)-asimilobine (3) and (+)-nornantenine (4). This is the first report on the
isolation of compounds 1, 3 and 4 from this plant. Compounds 2 and 4
showed good activity, whereas 1 and 3 displayed weak inhibition against
Streptococcus mutans (ATCC 25175). The results showed that compound
2 and 3 showed significant activity with a minimum inhibition
concentration (MIC) of 0.12 and 0.25 mg/mL, respectively. The present
study reports for the first time the antibacterial activity of the extract
of A. senegalensis and its constituents. As S. mutans is a rather resistant
bacteria, the MIC obtained during the present study is significant.
Antibacterial potential of alkaloids isolated from Annona senegalensis.
