African horse sickness caused by genome reassortment and reversion to virulence of live, attenuated vaccine viruses, South Africa, 2004-2014

Show simple item record

dc.contributor.author Weyer, Camilla Theresa
dc.contributor.author Grewar, John D.
dc.contributor.author Burger, Phillipa
dc.contributor.author Rossouw, Esthea
dc.contributor.author Lourens, Carina W.
dc.contributor.author Joone, Christopher
dc.contributor.author le Granje, Misha
dc.contributor.author Coetzee, Peter
dc.contributor.author Venter, Estelle Hildegard
dc.contributor.author Martin, Darren P.
dc.contributor.author MacLachlan, N.J. (James)
dc.contributor.author Guthrie, Alan John
dc.date.accessioned 2017-01-23T08:52:16Z
dc.date.available 2017-01-23T08:52:16Z
dc.date.issued 2016-12
dc.description.abstract African horse sickness (AHS) is a hemorrhagic viral fever of horses. It is the only equine disease for which the World Organization for Animal Health has introduced specific guidelines for member countries seeking official recognition of disease-free status. Since 1997, South Africa has maintained an AHS controlled area; however, sporadic outbreaks of AHS have occurred in this area. We compared the whole genome sequences of 39 AHS viruses (AHSVs) from field AHS cases to determine the source of 3 such outbreaks. Our analysis confirmed that individual outbreaks were caused by virulent revertants of AHSV type 1 live, attenuated vaccine (LAV) and reassortants with genome segments derived from AHSV types 1, 3, and 4 from a LAV used in South Africa. These findings show that despite effective protection of vaccinated horses, polyvalent LAV may, paradoxically, place susceptible horses at risk for AHS. en_ZA
dc.description.department Equine Research Centre en_ZA
dc.description.librarian am2017 en_ZA
dc.description.uri http://www.cdc.gov/eid en_ZA
dc.identifier.citation Weyer, CT, Grewar, JD, Burger, P, Rossouw, E, Lourens, C, Joone, C, Le Grange, M, Coetzee, P, Venter, E, Martin, DP, MacLachlan, NJ & Guthrie, AJ 2016, 'African horse sickness caused by genome reassortment and reversion to virulence of live, attenuated vaccine viruses, South Africa, 2004-2014', Emerging Infectious Diseases, vol. 22, no. 12, pp. 2087-2096. en_ZA
dc.identifier.issn 1080-6040 (print)
dc.identifier.issn 1080-6059 (online)
dc.identifier.other 10.3201/eid2212.160718
dc.identifier.uri http://hdl.handle.net/2263/58599
dc.language.iso en en_ZA
dc.publisher Centers for Disease Control and Prevention en_ZA
dc.rights Centers for Disease Control and Prevention (CDC) en_ZA
dc.subject Horses en_ZA
dc.subject African horse sickness (AHS) en_ZA
dc.subject South Africa (SA) en_ZA
dc.subject Live, attenuated vaccine (LAV) en_ZA
dc.subject African horse sickness virus (AHSV) en_ZA
dc.title African horse sickness caused by genome reassortment and reversion to virulence of live, attenuated vaccine viruses, South Africa, 2004-2014 en_ZA
dc.type Article en_ZA


Files in this item

This item appears in the following Collection(s)

Show simple item record