The role of Streptococcus pneumoniae in community-acquired pneumonia

Show simple item record Feldman, Charles Anderson, Ronald 2017-01-13T07:18:12Z 2016-12
dc.description.abstract Streptococcus pneumoniae (the pneumococcus) remains one of the most common causes of bacterial community-acquired pneumonia (CAP), encompassing infections mild enough to be treated on an outpatient basis, as well as those requiring hospital care, or even intensive care unit admission. This microorganism is associated with a significant burden of disease, causing substantial morbidity and mortality worldwide, and generating considerable health-care costs. The reason that pneumococcal CAP remains such a common cause of disease relates to the presence of several risk factors for this infection in patients throughout the world. Such risk factors include extremes of age, lifestyle factors, including smoking and alcohol abuse, and various underlying comorbid conditions, including congenital and acquired immunodeficiencies. This article will review various aspects of pneumococcal CAP, including the burden of pneumococcal disease, risk factors for pneumococcal infection, the occurrence of cardiovascular events in patients with pneumococcal CAP, the apparently pivotal role of pneumolysin, a major virulence factor of the pneumococcus, in the pathogenesis of severe infection and associated cardiac dysfunction, empiric antibiotic treatment for pneumococcal CAP, as well as adjunctive therapies, specifically those which target pneumolysin, and, finally, the mortality of such infections. en_ZA
dc.description.department Immunology en_ZA
dc.description.embargo 2017-12-31
dc.description.librarian hb2016 en_ZA
dc.description.sponsorship Charles Feldman is supported by the National Research Foundation of South Africa. en_ZA
dc.description.uri en_ZA
dc.identifier.citation Feldman, C & Anderson, R 2016, 'The role of Streptococcus pneumoniae in community-acquired pneumonia', Seminars in Respiratory and Critical Care Medicine, vol. 37, no. 6, pp. 806-818. en_ZA
dc.identifier.issn 1069-3424 (print)
dc.identifier.issn 1098-9048 (online)
dc.identifier.other 10.1055/s-0036-1592074
dc.language.iso en en_ZA
dc.publisher Thieme Publishing en_ZA
dc.rights © Thieme Medical Publishers en_ZA
dc.subject Antibiotics en_ZA
dc.subject Adjuvant therapy en_ZA
dc.subject Biomarkers en_ZA
dc.subject Burden of disease en_ZA
dc.subject Cardiac events en_ZA
dc.subject Mortality en_ZA
dc.subject Pneumococcus en_ZA
dc.subject Pneumolysin en_ZA
dc.subject Streptococcus pneumoniae en_ZA
dc.subject Community-acquired pneumonia (CAP) en_ZA
dc.title The role of Streptococcus pneumoniae in community-acquired pneumonia en_ZA
dc.type Postprint Article en_ZA

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