NMR-based metabolomics as a quality control tool for herbal products

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dc.contributor.author Heyman, Heino Martin
dc.contributor.author Meyer, J.J.M. (Jacobus Johannes Marion)
dc.date.accessioned 2017-01-12T06:13:09Z
dc.date.available 2017-01-12T06:13:09Z
dc.date.issued 2012-09
dc.description.abstract The full potential of the herbal market is mainly not realised due to the lack of knowledge of the chemical composition of most herbal products. The growth potential of the herbal medicine industry can only be achieved if the composition of herbal medicine is standardised to ensure proper quality control and accountability. Plant-based nuclear magnetic resonance metabolomics is one such way of ensuring quick and reliable quality control and metabolite profiling to ensure quality and reproducibility of herbal medicine. Nuclear magnetic resonance-based metabolomics is robust and relatively easy to use, thus ensuring that herbal medicine can be verified and quality controlled much quicker and more accurate than is currently the case. Although nuclear magnetic resonance is not as sensitive as other analytical techniques such as liquid chromatography and gas chromatography–mass spectroscopy, it is far more reproducible, non-destructive, covers a much wider dynamic range and sample preparation is simpler and quicker to use. Economical development of herbal medicine and the use of nuclear magnetic resonance-based metabolomics should go hand in hand for a better future for herbal medicine. In this review an introduction is given to herbal extracts as therapeutic agents and to the quality control aspects of herbal medicine by means of metabolomics. The experimental methodology for plant metabolomics which covers extraction, nuclear magnetic resonance analysis and multivariate data analysis is also discussed. Some examples are given on the possible applications of nuclear magnetic resonance-based metabolomics in the industry and finally the future of nuclear magnetic resonance-based metabolomics is discussed regarding advances in research and development. en_ZA
dc.description.department Plant Science en_ZA
dc.description.librarian hb2016 en_ZA
dc.description.uri http://www.elsevier.com/locate/sajb en_ZA
dc.identifier.citation Heyman, HM & Meyer, JJM 2012, 'NMR-based metabolomics as a quality control tool for herbal products', South African Journal of Botany, vol. 82, pp. 21-32. en_ZA
dc.identifier.issn 0254-6299 (print)
dc.identifier.issn 1727-9321 (online)
dc.identifier.other 10.1016/j.sajb.2012.04.001
dc.identifier.uri http://hdl.handle.net/2263/58487
dc.language.iso en en_ZA
dc.publisher Elsevier en_ZA
dc.rights © 2012 SAAB. Published by Elsevier B.V. All rights reserved. Open Access funded by SAAB under a Creative Commons license. en_ZA
dc.subject Herbal medicine en_ZA
dc.subject Metabolomics en_ZA
dc.subject Nuclear magnetic resonance spectroscopy en_ZA
dc.subject Quality control en_ZA
dc.title NMR-based metabolomics as a quality control tool for herbal products en_ZA
dc.type Article en_ZA


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