dc.contributor.author |
Bornman, Maria S. (Riana)
|
|
dc.contributor.author |
Chevrier, J.
|
|
dc.contributor.author |
Rauch, S.
|
|
dc.contributor.author |
Crause, Madelein
|
|
dc.contributor.author |
Obida, Muvhulawa
|
|
dc.contributor.author |
Sathyanarayana, S.
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|
dc.contributor.author |
Barr, D.B.
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|
dc.contributor.author |
Eskenazi, B.
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|
dc.date.accessioned |
2017-01-10T06:10:57Z |
|
dc.date.issued |
2016-07 |
|
dc.description.abstract |
Dichlorodiphenyltrichloroethane (DDT) is used for malaria control by 10 countries, nine of which are in Africa. Technical DDT contains various isomers with 65-80% insecticidal p,p'-DDT and 15-21% o,p'-DDT, an estrogenic chemical, while the persistent metabolite of p,p'-DDT, dichlorodiphenyldichloroethylene (p,p'-DDE), is an antiandrogen. In utero antiandrogenic exposure reduces anogenital distance in animal models and the anal position index in a single study. This study examined the associations between mother's serum DDT and DDE levels at delivery and anogenital distance in their children at birth and age 1 year. Data were collected as part of the Venda Health Examination of Mothers, Babies and their Environment (VHEMBE), a birth cohort study located in rural South Africa. DDT and DDE concentrations were measured in blood samples collected from 752 mothers at delivery. Anogenital distance measurements, taken at birth (n = 671) and age 1 year (n = 674), included anofourchette and anoclitoral distances in girls, and anoscrotal and anopenile lengths in boys. We also measured anococcygeal and coccyx-fourchette distances in girls, while in boys, we measured anococcygeal and coccyx-scrotal distances as well as penile length and penile width. The anal position index is calculated for both sexes as anoscrotal/coccyx-scrotal in boys and anofourchette/coccyx-fourchette in girls. We found no associations between p,p'-DDT/-DDE or o,p'-DDT and anogenital distance measurements at birth in either boys or girls. At 1 year, o,p'-DDE was negatively associated with anofourchette in girls (β =-1.32 mm, 95% confidence interval (CI) = -2.27, -0.38) and positively associated with penile width in boys (β = 0.30 mm, 95% CI = 0.00, 0.60). The results do not suggest an overt antiandrogenic or estrogenic effect on anogenital distance after long-term DDT exposure. These weak associations may be due to chance. |
en_ZA |
dc.description.department |
School of Health Systems and Public Health (SHSPH) |
en_ZA |
dc.description.embargo |
2017-07-31 |
|
dc.description.librarian |
hb2016 |
en_ZA |
dc.description.uri |
http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)2047-2927 |
en_ZA |
dc.identifier.citation |
Bornman, MS, Chevrier, J, Rauch, S, Crause, M, Obida, M, Sathyanarayana, S, Barr, DB & Eskenazi, B 2016, 'Dichlorodiphenyltrichloroethane exposure and anogenital distance in the Venda Health Examination of Mothers, Babies and their Environment (VHEMBE) birth cohort study, South Africa', Andrology, vol. 4, no. 4, pp. 608-615. |
en_ZA |
dc.identifier.issn |
2047-2919 (print) |
|
dc.identifier.issn |
2047-2927(online) |
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dc.identifier.other |
10.1111/andr.12235 |
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dc.identifier.uri |
http://hdl.handle.net/2263/58455 |
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dc.language.iso |
en |
en_ZA |
dc.publisher |
Wiley |
en_ZA |
dc.rights |
© 2016 American Society of Andrology and European Academy of Andrology. This is the pre-peer reviewed version of the following article : Dichlorodiphenyltrichloroethane exposure and anogenital distance in the Venda Health Examination of Mothers, Babies and their Environment (VHEMBE) birth cohort study, South Africa , Journal of Andrology, vol. 4, no. 4, pp. 608-615, 2016. doi : 10.1111/andr.12235. The definite version is available at : http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)2047-2927. |
en_ZA |
dc.subject |
Anogenital distance |
en_ZA |
dc.subject |
Boys |
en_ZA |
dc.subject |
Girls |
en_ZA |
dc.subject |
Dichlorodiphenyltrichloroethane (DDT) |
en_ZA |
dc.subject |
Dichlorodiphenyldichloroethylene (DDE) |
en_ZA |
dc.subject |
Venda health examination of mothers, babies and their environment (VHEMBE) |
en_ZA |
dc.title |
Dichlorodiphenyltrichloroethane exposure and anogenital distance in the Venda Health Examination of Mothers, Babies and their Environment (VHEMBE) birth cohort study, South Africa |
en_ZA |
dc.type |
Postprint Article |
en_ZA |