Nuclear organisation of some immunohistochemically identifiable neural systems in three Afrotherian species-Potomogale velox, Amblysomus hottentotus and Petrodromus tetradactylus

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dc.contributor.author Calvey, Tanya
dc.contributor.author Patzke, Nina
dc.contributor.author Kaswera, Consolate
dc.contributor.author Gilissen, Emmanuel
dc.contributor.author Bennett, Nigel C., 1961-
dc.contributor.author Manger, Paul R.
dc.date.accessioned 2016-12-15T05:27:54Z
dc.date.available 2016-12-15T05:27:54Z
dc.date.issued 2013-05
dc.description.abstract The present study describes the organization of the cholinergic, catecholaminergic, serotonergic and orexinergic (hypocretinergic) neurons in the brains of the giant otter shrew, the Hottentot golden mole and the four-toed sengi, three members of the mammalian super order Afrotheria. The aim of the present study was to investigate the possible differences in the nuclear complement of these neural systems in comparison to previous studies on other Afrotheria species and other mammalian species. Brains of the golden mole, sengi and giant otter shrew were coronally sectioned and immunohistochemically stained with antibodies against cholineacetyl-transferase, tyrosine hydroxylase, serotonin and orexin-A. The majority of nuclei revealed in the current study were similar between the species investigated, to other Afrotherian species investigated, and to other mammals, but certain differences in the nuclear complement highlighted phylogenetic interrelationships. The golden mole was seen to have cholinergic interneurons in the cerebral cortex, hippocampus, olfactory bulb and amygdala. The four-toed sengi had cholinergic neurons in both colliculi and in the cochlear nucleus, but lacked the catecholaminergic A15d group in the hypothalamus. In both the golden mole and the four-toed sengi, the locus coeruleus (A6d group) was made up of few neurons. The golden mole also exhibited an unusual foreshortening of the brain, such that a major kink in the brainstem was evident. The results of this study, framed in a phylogenetic context, appear to indicate that the golden mole and four-toed sengi share a more recent common ancestor that diverged from the tenrec lineage early in the phylogenetic history of the Afrotherians. en_ZA
dc.description.department Mammal Research Institute en_ZA
dc.description.department Zoology and Entomology en_ZA
dc.description.librarian hb2016 en_ZA
dc.description.sponsorship The South African National Research Foundation (PRM and NCB), the Belgian co-operation service at the Royal Museum for Central Africa (EG), and by a fellowship within the Postdoctoral-Program of the German Academic Exchange Service, DAAD (NP). en_ZA
dc.description.uri http://www.elsevier.com/locate/jchemneu en_ZA
dc.identifier.citation Calvey, T, Patzke, N, Kaswera, C, Gilissen, E, Bennett, NC & Manger, PR 2013, 'Nuclear organisation of some immunohistochemically identifiable neural systems in three Afrotherian species-Potomogale velox, Amblysomus hottentotus and Petrodromus tetradactylus', Journal of Chemical Neuroanatomy, vol. 50-51, no. 5, pp. 48-65. en_ZA
dc.identifier.issn 0891-0618 (print)
dc.identifier.issn 1873-6300 (online)
dc.identifier.other 10.1016/j.jchemneu.2013.01.002
dc.identifier.uri http://hdl.handle.net/2263/58403
dc.language.iso en en_ZA
dc.publisher Elsevier en_ZA
dc.rights © 2013 Elsevier B.V. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Journal of Chemical Neuroanatomy. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. A definitive version was subsequently published in Journal of Chemical Neuroanatomy, vol. 50-51, pp. 48-65, 2013. doi : 10.1016/j.jchemneu.2013.01.002. en_ZA
dc.subject Choline acetyltransferase en_ZA
dc.subject Tyrosine hydroxylase en_ZA
dc.subject Serotonin en_ZA
dc.subject Hypocretin en_ZA
dc.subject Orexin en_ZA
dc.subject Evolution en_ZA
dc.subject Afrotherian en_ZA
dc.title Nuclear organisation of some immunohistochemically identifiable neural systems in three Afrotherian species-Potomogale velox, Amblysomus hottentotus and Petrodromus tetradactylus en_ZA
dc.type Postprint Article en_ZA


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