The clinical relevance of altered fibrinogen packaging in the presence of 17β-estradiol and progesterone

Show simple item record Swanepoel, A.C. (Albe Carina) Visagie, Amcois De Lange, Zelda Emmerson, Odette Nielsen, Vance G. Pretorius, Etheresia 2016-12-05T11:09:08Z 2016-10
dc.description.abstract BACKGROUND : The effect of endogenous hormone concentrations, specifically 17β-estradiol and progesterone, on fibrin network formation has not been established. OBJECTIVES : It is essential to understand natural hormone mechanisms since these hormones are still present in circulation while hormonal contraceptives, which are associated with increased risk of venous thromboembolism, are used. METHODS : Due to the fact that these hormones are known to increase hypercoagulability and the prothrombotic state scanning electron microscopy (SEM), atomic force microscopy (AFM), thromboelastography (TEG) and turbidimetry were employed to investigate the morphology, surface roughness, viscoelastic properties and formation and lysis of fibrin. RESULTS : 17β-estradiol and progesterone showed hypercoagulable viscoelastic properties and decreased the diameter and surface roughness of fibrin while increasing dense matted deposit occurrence. Our results suggest that the additional burden of hormonal load, together with the presence of endogenous estrogen and progesterone, may result in a prothrombotic and hypercoagulable state in females with an inflammatory predisposition. CONCLUSION : Our results are of clinical importance when considering hormones as either pathological agent or therapeutic intervention as will be assessed in future investigation. en_ZA
dc.description.department Physiology en_ZA
dc.description.embargo 2017-10-31
dc.description.librarian hb2016 en_ZA
dc.description.sponsorship Swanepoel received funding from the National Research Foundation (NRF) of South Africa and Pretorius received funding from the Medical Research Council (MRC) of South Africa. en_ZA
dc.description.uri en_ZA
dc.identifier.citation Swanepoel, AC, Visagie, A, De Lange, Z, Emmerson, O, Nielsen, VG & Pretorius, E 2016, 'The clinical relevance of altered fibrinogen packaging in the presence of 17β-estradiol and progesterone', Thrombosis Research, vol. 146, pp. 23-34. en_ZA
dc.identifier.issn 0049-3848
dc.identifier.other 10.1016/j.thromres.2016.08.022
dc.language.iso en en_ZA
dc.publisher Elsevier en_ZA
dc.rights © 2016 Elsevier Ltd. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Thrombosis Research . Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. A definitive version was subsequently published in Thrombosis Research, vol. 146, pp. 23-34, 2016. doi : 10.1016/j.thromres.2016.08.022. en_ZA
dc.subject 17β-estradiol en_ZA
dc.subject Fibrinogen en_ZA
dc.subject Fibrin en_ZA
dc.subject Progesterone en_ZA
dc.subject Thrombophilia en_ZA
dc.subject Circulation en_ZA
dc.subject Hormonal contraceptives en_ZA
dc.subject Venous thromboembolism en_ZA
dc.subject Natural hormone en_ZA
dc.subject State scanning electron microscopy (SEM) en_ZA
dc.subject Atomic force microscopy (AFM) en_ZA
dc.subject Thromboelastography (TEG) en_ZA
dc.subject Turbidimetry en_ZA
dc.title The clinical relevance of altered fibrinogen packaging in the presence of 17β-estradiol and progesterone en_ZA
dc.type Postprint Article en_ZA

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