dc.contributor.author |
Rauff, Dionne
|
|
dc.contributor.author |
Strydom, Christine
|
|
dc.contributor.author |
Abolnik, Celia
|
|
dc.date.accessioned |
2016-10-12T05:31:46Z |
|
dc.date.issued |
2016-11 |
|
dc.description.abstract |
The evolutionary dynamics of chicken-origin H6N2 viruses isolated in South Africa between 2002 and 2013
were investigated. Sub-lineages I and II continued to co-circulate under vaccination pressure, but sublineage
I, from which the inactivated vaccine was derived, displayed a markedly higher mutation rate and a
three-fold increase in the emergence of potential antigenic sites on the globular head of HA compared to
sub-lineage II. Immunological pressure culminated in a critical phenotypic change as four of the five
isolates from 2012-2013 had lost the ability to haemagglutinate chicken erythrocytes, correlating with a
pattern of predicted O-glycosylation sites at residues 134, 137 and 141 within the critical 130 loop of the
receptor binding domain site. Coassortment of the HA, NA and M genes in the respective sub-lineages
contrasted reassortment of the other internal protein genes, and the vaccine seed strain itself was the
probable donor of segments to sub-lineage II field strains. |
en_ZA |
dc.description.department |
Production Animal Studies |
en_ZA |
dc.description.department |
Veterinary Tropical Diseases |
en_ZA |
dc.description.embargo |
2017-11-30 |
|
dc.description.librarian |
hb2016 |
en_ZA |
dc.description.sponsorship |
Deltamune (Pty) Ltd, and an Incentive Funding for Rated Researchers grant from
the National Research Foundation (C Abolnik). D. Rauff was supported by a grant from the Health and
Welfare Sector Education and Training Authority (HWSETA). |
en_ZA |
dc.description.uri |
http://www.elsevier.com/locate/yviro |
en_ZA |
dc.identifier.citation |
Rauff, D, Strydom, C & Abolnik, C 2016, 'Evolutionary consequences of a decade of vaccination against subtype H6N2 influenza', Virology, vol. 498, pp. 226-239. |
en_ZA |
dc.identifier.issn |
0042-6822 (print) |
|
dc.identifier.issn |
1096-0341 (online) |
|
dc.identifier.other |
10.1016/j.virol.2016.08.035 |
|
dc.identifier.other |
23093208700 |
|
dc.identifier.other |
N-9324-2014 |
|
dc.identifier.uri |
http://hdl.handle.net/2263/57102 |
|
dc.language.iso |
en |
en_ZA |
dc.publisher |
Elsevier |
en_ZA |
dc.rights |
© 2016 Elsevier Inc. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Virology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. A definitive version was subsequently published in Virology, vol. 498, pp. 226-239, 2016. doi : 10.1016/j.virol.2016.08.035. |
en_ZA |
dc.subject |
Avian influenza |
en_ZA |
dc.subject |
H6N2 |
en_ZA |
dc.subject |
Glycosylation |
en_ZA |
dc.subject |
Reassortment |
en_ZA |
dc.subject |
Coassortment |
en_ZA |
dc.subject |
Genetic drift |
en_ZA |
dc.subject |
Vaccines |
en_ZA |
dc.subject.lcsh |
Poultry -- Diseases |
en_ZA |
dc.title |
Evolutionary consequences of a decade of vaccination against subtype H6N2 influenza |
en_ZA |
dc.type |
Postprint Article |
en_ZA |