The chlorination behaviour and environmental fate of the antiretroviral drug Nevirapine in South African surface water

Show simple item record Wood, Timothy Paul Basson, A.E. Duvenage, C. Rohwer, Egmont Richard 2016-09-21T07:44:04Z 2016-11
dc.description.abstract The wastewater treatment process, besides discharging pharmaceuticals into the environment, has been found to result in the formation of a variety of undescribed compounds. Here we investigate the laboratory scale chlorination of the commonly used anti-HIV drug Nevirapine, characterise its disinfection transformation products (DTPs), and using liquid chromatography with high resolution mass spectrometry, screen environmental surface water for these DTPs. Chlorination of Nevirapine was scaled up, fractioned by preparative chromatography and the fractions were tested in vitro for toxicity and anti-HIV activity. Nevirapine was found to be resistant to degradation at relevant chlorination levels, which may partially explain its ubiquitous presence in South African surface water. During simulated chlorination, a variety of DTPs with varying properties were formed, some of which were detected in the environment, close to wastewater treatment plants. Interestingly, some of these compounds, although not as toxic as Nevirapine, retained antiviral activity. Further purification and synthesis is required to fully characterise these novel molecules. en_ZA
dc.description.department Chemistry en_ZA
dc.description.embargo 2017-11-30
dc.description.librarian hb2016 en_ZA
dc.description.sponsorship South African Military Health Services en_ZA
dc.description.uri en_ZA
dc.identifier.citation Wood, TP, Basson, AE, Duvenage, C & Rohwer, ER 2016, 'The chlorination behaviour and environmental fate of the antiretroviral drug nevirapine in South African surface water', Water Research, vol. 104, pp. 349-360. en_ZA
dc.identifier.issn 0043-1354 (print)
dc.identifier.issn 1879-2448 (online)
dc.identifier.other 10.1016/j.watres.2016.08.038
dc.language.iso en en_ZA
dc.publisher Elsevier en_ZA
dc.rights © 2016 Elsevier Ltd. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Water Research. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. A definitive version was subsequently published in Water Research, vol. 104, pp. 349-360, 2016. doi: 10.1016/j.watres.2016.08.038. en_ZA
dc.subject Nevirapine en_ZA
dc.subject Chlorination en_ZA
dc.subject Wastewater en_ZA
dc.subject LC-MS en_ZA
dc.subject Surface water en_ZA
dc.subject LC-QTOF en_ZA
dc.subject Disinfection transformation products (DTPs) en_ZA
dc.title The chlorination behaviour and environmental fate of the antiretroviral drug Nevirapine in South African surface water en_ZA
dc.type Postprint Article en_ZA

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