Sirtuin 1 rs1467568 and rs7895833 in South African Indians with early-onset coronary artery disease

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dc.contributor.author Ramkaran, Prithiksha
dc.contributor.author Phulukdaree, Alisa
dc.contributor.author Khan, Sajidah
dc.contributor.author Moodley, Devapregasan
dc.contributor.author Chuturgoon, Anil A.
dc.date.accessioned 2016-09-12T07:15:30Z
dc.date.available 2016-09-12T07:15:30Z
dc.date.issued 2016-07
dc.description.abstract BACKGROUND : Sirtuin 1 (SIRT1), a class III histone deacetylase, has been identified as a candidate molecule affecting the epigenetic mechanisms of cardiovascular disease (CVD). Previous studies have shown that some SIRT1 single-nucleotide polymorphisms (SNPs) are associated with body mass index, diabetes, blood pressure, cholesterol metabolism and coronary artery calcification. We investigated two A>G SIRT1 SNPs, rs1467568 and rs7895833, in young South African (SA) Indians with coronary artery disease (CAD) and compared them to Indian and black controls. METHODS : For rs1467568, a total of 287 subjects were recruited into this study (104 CAD patients, 99 age-, gender- and race-matched controls, and 84 age- and gender-matched black controls). For rs7895833, a total of 281 subjects were recruited into this study (100 CAD patients, 99 age-, gender- and race-matched controls, and 82 age- and gender-matched black controls). All patients were male, of Indian ethnicity, stable CAD confirmed on angiography, mean age 37.5 years; range 24–45. All subjects were genotyped using TaqMan SNP genotyping assays. RESULTS : The variant allele for both SNPs was found at a higher frequency in the total Indian group compared to the total black population (rs1467568: 41 vs 18.5%, respectively, p < 0.0001, OR = 3.190, 95% CI: 2.058–40943; and rs7895833: 41 vs 22%, respectively, p < 0.0001, OR = 2.466, 95% CI: 1.620– 3.755). Indian controls presented with a higher frequency for both SNPs compared to black controls (rs1467568: 40 vs 18.5%, respectively, p < 0.0001, OR = 2.996, 95% CI: 1.850– 4.853; and rs7895833: 41 vs 22%, respectively, p < 0.0001, OR = 2.513, 95% CI: 1.578–4.004). No difference was seen in the distribution of both SNPs between CAD patients and either control group. We did not observe any association between the SNPs and clinical parameters in CAD patients and controls. CONCLUSION : Both SNP variant alleles occurred more frequently in SA Indians than in SA blacks. A larger study group and further analysis is required to assess whether these SIRT1 SNPs may serve as risk factors that contribute to Indians developing early-onset CAD. en_ZA
dc.description.department Physiology en_ZA
dc.description.librarian am2016 en_ZA
dc.description.sponsorship The National Research Foundation (NRF) for a scholarship and UKZN (College of Health Sciences). en_ZA
dc.description.uri www.cvja.co.za en_ZA
dc.identifier.citation Ramkaran, P, Phulukdaree, A, Khan, S, Moodley, D & Chuturgoon, AA 2016, 'Sirtuin 1 rs1467568 and rs7895833 in South African Indians with early-onset coronary artery disease', Cardiovascular Journal of Africa, vol. 27, no. 4, pp. 213-217. en_ZA
dc.identifier.issn 1995-1892 (print)
dc.identifier.issn 1680-0745 (online)
dc.identifier.other 10.5830/CVJA-2015-085
dc.identifier.uri http://hdl.handle.net/2263/56700
dc.language.iso en en_ZA
dc.publisher Clinics Cardive en_ZA
dc.rights © Clinics Cardive Publishing (Pty) Ltd. en_ZA
dc.subject rs1467568 en_ZA
dc.subject rs7895833 en_ZA
dc.subject South African Indians en_ZA
dc.subject Sirtuin 1 (SIRT1) en_ZA
dc.subject Cardiovascular disease (CVD) en_ZA
dc.subject Single-nucleotide polymorphisms (SNPs) en_ZA
dc.subject Coronary artery disease (CAD) en_ZA
dc.title Sirtuin 1 rs1467568 and rs7895833 in South African Indians with early-onset coronary artery disease en_ZA
dc.type Article en_ZA


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