Development and ultra-structure of an ultra-thin silicone epidermis of bioengineered alternative tissue

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dc.contributor.author Wessels, Quenton
dc.contributor.author Pretorius, Etheresia
dc.date.accessioned 2016-09-02T06:48:15Z
dc.date.available 2016-09-02T06:48:15Z
dc.date.issued 2015-08
dc.description.abstract Burn wound care today has a primary objective of temporary or permanent wound closure. Commercially available engineered alternative tissues have become a valuable adjunct to the treatment of burn injuries. Their constituents can be biological, alloplastic or a combination of both. Here the authors describe the aspects of the development of a siloxane epidermis for a collagen-glycosaminoglycan and for nylon-based artificial skin replacement products. A method to fabricate an ultra-thin epidermal equivalent is described. Pores, to allow the escape of wound exudate, were punched and a tri-filament nylon mesh or collagen scaffold was imbedded and silicone polymerisation followed at 120°C for 5 minutes. The ultra-structure of these bilaminates was assessed through scanning electron microscopy. An ultra-thin biomedical grade siloxane film was reliably created through precision coating on a pre-treated polyethylene terephthalate carrier. en_ZA
dc.description.department Anatomy en_ZA
dc.description.librarian hb2016 en_ZA
dc.description.sponsorship Southern Group of Companies, Gauteng, South Africa. en_ZA
dc.description.uri http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1742-481X en_ZA
dc.identifier.citation Wessels, Q & Pretorius, E 2015, 'Development and ultra-structure of an ultra-thin silicone epidermis of bioengineered alternative tissue', International Wound Journal, vol. 12, no. 4, pp. 428-431 en_ZA
dc.identifier.issn 1742-4801(print)
dc.identifier.issn 1742-481X (online)
dc.identifier.other 10.1111/iwj.12126
dc.identifier.uri http://hdl.handle.net/2263/56583
dc.language.iso en en_ZA
dc.publisher Wiley en_ZA
dc.rights © 2013 The Authors. International Wound Journal © 2013 Medicalhelplines.com Inc and John Wiley & Sons Ltd. This is the pre-peer reviewed version of the following article : Development and ultra-structure of an ultra-thin silicone epidermis of bioengineered alternative tissue, International Wound Journal, vol. 12, no. 4, pp. 428-431, 2015. doi : 10.1111/iwj.12126. The definite version is available at : http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1742-481X. en_ZA
dc.subject Bioengineered alternative tissue en_ZA
dc.subject Burn wound en_ZA
dc.subject Siloxane epidermis en_ZA
dc.subject Temporary skin substitute en_ZA
dc.subject Ultra-thin membrane en_ZA
dc.title Development and ultra-structure of an ultra-thin silicone epidermis of bioengineered alternative tissue en_ZA
dc.type Postprint Article en_ZA


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