Antibacterial and antioxidant xanthones and benzophenone from Garcinia smeathmannii

Show simple item record Fouotsa, Hugues Lannang, Alain Meli Dzoyem, Jean Paul Tatsimo, Simplice J.N. Neumann, Beate Mbazoa, Celine Djama Razakarivony, Andrianambinina Andriamarolahy Nkengfack, Augustin Ephrem Eloff, Jacobus Nicolaas Sewald, Norbert 2016-08-30T15:00:36Z 2016-08-30T15:00:36Z 2015-05
dc.description.abstract A new prenylated xanthone, 1,3,5,8-tetrahydroxy-2-(3-methybut-2-enyl)-4-(3,7- dimethylocta-2,6-dienyl) xanthone (1), and a new benzophenone (2), together with four known xanthone derivatives, cheffouxanthone (3), smeathxanthone A (4), smeathxanthone B (5), ananixanthone (6), and two pentacyclic triterpenes, epi-friedelinol (7) and friedelin (8), were isolated from the stem bark of Garcinia smeathmannii. The structures of the compounds were elucidated on the basis of 1D and 2D NMR experiments, and compound 2 was further characterized and confirmed by single X-ray analysis. Compounds 1, 2, and 3 exhibited the most prominent Garcinia activity against gram-positive Enterococcus faecalis with minimal inhibitory concentration values of 8, 8, and 2 μg/mL, respectively, while compounds 1, 3, 4, and 6 showed the capacity to scavenge free radicals. en_ZA
dc.description.department Paraclinical Sciences en_ZA
dc.description.librarian hb2016 en_ZA
dc.description.sponsorship A. M. L. would like to thank the Alexander von Humboldt-Stiftung for the award of a Georg Forster Fellowship for Experienced Researchers (ID N°1 137 675). H. F. would like to acknowledge the German Academic Exchange Service (DAAD, Referat 412; PKZ A/12/904 859) for the fellowship at Bielefeld University (Germany). en_ZA
dc.description.uri en_ZA
dc.identifier.citation Fouotsa, H, Lannang, AM, Dzoyem, JP, Tatsimo, SJN, Neumann, B, Mbazoa, CD, Razakarivony, AA, Nkengfack, AE, Eloff, JN & Sewald, N 2015, 'Antibacterial and antioxidant xanthones and benzophenone from Garcinia smeathmannii', Planta Medica, vol. 81, no. 7, pp. 594-599. en_ZA
dc.identifier.issn 0036-8075 (print)
dc.identifier.issn 1095-9203 (online)
dc.identifier.other 10.1055/s-0035-1545841
dc.identifier.other 7005589445
dc.identifier.other E-6204-2012
dc.language.iso en en_ZA
dc.publisher American Association for the Advancement of Science en_ZA
dc.rights © 2015 Georg Thieme Verlag KG. en_ZA
dc.subject Garcinia smeathmannii en_ZA
dc.subject Guttiferae en_ZA
dc.subject Xanthone en_ZA
dc.subject Benzophenone en_ZA
dc.subject Antibacteria en_ZA
dc.subject Antioxidants en_ZA
dc.title Antibacterial and antioxidant xanthones and benzophenone from Garcinia smeathmannii en_ZA
dc.type Postprint Article en_ZA

Files in this item

This item appears in the following Collection(s)

Show simple item record