dc.contributor.author |
Patrick, Sean Mark
|
|
dc.contributor.author |
Bornman, Maria S. (Riana)
|
|
dc.contributor.author |
Joubert, Annie M.
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|
dc.contributor.author |
Pitts, Neville
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|
dc.contributor.author |
Naidoo, Vinny
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|
dc.contributor.author |
De Jager, Christiaan
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|
dc.date.accessioned |
2016-08-05T08:15:21Z |
|
dc.date.issued |
2016-06 |
|
dc.description.abstract |
The male reproductive system is sensitive to endocrine disrupting chemicals (EDCs) during critical developmental windows. Male Sprague-Dawley rats were exposed in utero-, during lactation- and directly to 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT), 1,1,-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) and a mixture of DDT, deltamethrin (DM), p-nonylphenol (p-NP) and phytoestrogens, at concentrations found in a malaria-area. After dosing for 104 days, histological assessments and reproductive-endpoints were assessed. The anogenital distance (AGD) (P = 0.005) was shorter in the mixture-exposed group, while the prostate mass (P = 0.018) was higher in the DDT-exposed group. A higher testicular mass and abnormal histology was observed in the DDT-(P = 0.019), DDE-(P = 0.047) and mixture-exposed (P < 0.005) groups. This study shows that in utero-, lactational- and direct exposure to EDCs present in a malaria-area negatively affects male reproductive parameters in rats. These findings raise concerns to EDC-exposures to mothers living in malaria-areas and the reproductive health of their male offspring. |
en_ZA |
dc.description.department |
Physiology |
en_ZA |
dc.description.department |
School of Health Systems and Public Health (SHSPH) |
en_ZA |
dc.description.embargo |
2017-06-30 |
|
dc.description.librarian |
hb2016 |
en_ZA |
dc.description.sponsorship |
Medical Research Council of South Africa |
en_ZA |
dc.identifier.citation |
Patrick, SM, Bornman, MS, Joubert, AM, Pitts, N, Naidoo, V & De Jager, C 2016, 'Effects of environmental endocrine disruptors, including insecticides used for malaria vector control on reproductive parameters of male rats', Reproductive Toxicology, vol. 61, pp. 19-27. |
en_ZA |
dc.identifier.issn |
0890-6238 |
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dc.identifier.other |
10.1016/j.reprotox.2016.02.015 |
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dc.identifier.uri |
http://hdl.handle.net/2263/56216 |
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dc.language.iso |
en |
en_ZA |
dc.publisher |
Elsevier |
en_ZA |
dc.rights |
© 2016 Elsevier Inc. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Reproductive Toxicology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Reproductive Toxicology, vol. 61, pp. 19-27, 2016. doi : 10.1016/j.reprotox.2016.02.015. |
en_ZA |
dc.subject |
DDT |
en_ZA |
dc.subject |
DDE |
en_ZA |
dc.subject |
p-Nonylphenol |
en_ZA |
dc.subject |
Phytoestrogens |
en_ZA |
dc.subject |
South Africa (SA) |
en_ZA |
dc.subject |
Endocrine disrupting chemicals (EDCs) |
en_ZA |
dc.subject |
Deltamethrin (DM) |
en_ZA |
dc.subject |
P-nonylphenol (p-NP) |
en_ZA |
dc.title |
Effects of environmental endocrine disruptors, including insecticides used for malaria vector control on reproductive parameters of male rats |
en_ZA |
dc.type |
Postprint Article |
en_ZA |