Effects of environmental endocrine disruptors, including insecticides used for malaria vector control on reproductive parameters of male rats

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Authors

Patrick, Sean Mark
Bornman, Maria S. (Riana)
Joubert, Annie M.
Pitts, Neville
Naidoo, Vinny
De Jager, Christiaan

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Journal ISSN

Volume Title

Publisher

Elsevier

Abstract

The male reproductive system is sensitive to endocrine disrupting chemicals (EDCs) during critical developmental windows. Male Sprague-Dawley rats were exposed in utero-, during lactation- and directly to 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT), 1,1,-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) and a mixture of DDT, deltamethrin (DM), p-nonylphenol (p-NP) and phytoestrogens, at concentrations found in a malaria-area. After dosing for 104 days, histological assessments and reproductive-endpoints were assessed. The anogenital distance (AGD) (P = 0.005) was shorter in the mixture-exposed group, while the prostate mass (P = 0.018) was higher in the DDT-exposed group. A higher testicular mass and abnormal histology was observed in the DDT-(P = 0.019), DDE-(P = 0.047) and mixture-exposed (P < 0.005) groups. This study shows that in utero-, lactational- and direct exposure to EDCs present in a malaria-area negatively affects male reproductive parameters in rats. These findings raise concerns to EDC-exposures to mothers living in malaria-areas and the reproductive health of their male offspring.

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Keywords

DDT, DDE, p-Nonylphenol, Phytoestrogens, South Africa (SA), Endocrine disrupting chemicals (EDCs), Deltamethrin (DM), P-nonylphenol (p-NP)

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Citation

Patrick, SM, Bornman, MS, Joubert, AM, Pitts, N, Naidoo, V & De Jager, C 2016, 'Effects of environmental endocrine disruptors, including insecticides used for malaria vector control on reproductive parameters of male rats', Reproductive Toxicology, vol. 61, pp. 19-27.