Effects of environmental endocrine disruptors, including insecticides used for malaria vector control on reproductive parameters of male rats
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Date
Authors
Patrick, Sean Mark
Bornman, Maria S. (Riana)
Joubert, Annie M.
Pitts, Neville
Naidoo, Vinny
De Jager, Christiaan
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
The male reproductive system is sensitive to endocrine disrupting chemicals (EDCs) during critical developmental windows. Male Sprague-Dawley rats were exposed in utero-, during lactation- and directly to 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT), 1,1,-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) and a mixture of DDT, deltamethrin (DM), p-nonylphenol (p-NP) and phytoestrogens, at concentrations found in a malaria-area. After dosing for 104 days, histological assessments and reproductive-endpoints were assessed. The anogenital distance (AGD) (P = 0.005) was shorter in the mixture-exposed group, while the prostate mass (P = 0.018) was higher in the DDT-exposed group. A higher testicular mass and abnormal histology was observed in the DDT-(P = 0.019), DDE-(P = 0.047) and mixture-exposed (P < 0.005) groups. This study shows that in utero-, lactational- and direct exposure to EDCs present in a malaria-area negatively affects male reproductive parameters in rats. These findings raise concerns to EDC-exposures to mothers living in malaria-areas and the reproductive health of their male offspring.
Description
Keywords
DDT, DDE, p-Nonylphenol, Phytoestrogens, South Africa (SA), Endocrine disrupting chemicals (EDCs), Deltamethrin (DM), P-nonylphenol (p-NP)
Sustainable Development Goals
Citation
Patrick, SM, Bornman, MS, Joubert, AM, Pitts, N, Naidoo, V & De Jager, C 2016, 'Effects of environmental endocrine disruptors, including insecticides used for malaria vector control on reproductive parameters of male rats', Reproductive Toxicology, vol. 61, pp. 19-27.