Molecular communication model for targeted drug delivery in multiple disease sites with diversely expressed enzymes

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dc.contributor.author Chude-Okonkwo, Uche A.K.
dc.contributor.author Malekian, Reza
dc.contributor.author Maharaj, Bodhaswar Tikanath Jugpershad
dc.date.accessioned 2016-08-01T08:13:20Z
dc.date.available 2016-08-01T08:13:20Z
dc.date.issued 2016-04
dc.description.abstract Targeted drug delivery (TDD) for disease therapy using liposomes as nanocarriers has received extensive attention in the literature. The liposome's ability to incorporate capabilities such as long circulation, stimuli responsiveness, and targeting characteristics, makes it a versatile nanocarrier. Timely drug release at the targeted site requires that trigger stimuli such as pH, light, and enzymes be uniquely overexpressed at the targeted site. However, in some cases, the targeted sites may not express trigger stimuli significantly, hence, achieving effective TDD at those sites is challenging. In this paper, we present a molecular communication-based TDD model for the delivery of therapeutic drugs to multiple sites that may or may not express trigger stimuli. The nanotransmitter and nanoreceiver models for the molecular communication system are presented. Here, the nanotransmitter and nanoreceiver are injected into the targeted body system's blood network. The compartmental pharmacokinetics model is employed to model the transportation of these therapeutic nanocarriers to the targeted sites where they are meant to anchor before the delivery process commences. We also provide analytical expressions for the delivered drug concentration. The effectiveness of the proposed model is investigated for drug delivery on tissue surfaces. Results show that the effectiveness of the proposed molecular communication-based TDD depends on parameters such as the total transmitter volume capacity, the receiver radius, the diffusion characteristic of the microenvironment of the targeted sites, and the concentration of the enzymes associated with the nanotransmitter and the nanoreceiver designs. en_ZA
dc.description.department Electrical, Electronic and Computer Engineering en_ZA
dc.description.librarian hb2016 en_ZA
dc.description.uri http://ieeexplore.ieee.org/xpl/RecentIssue.jsp?punumber=7728 en_ZA
dc.identifier.citation Chude-Okonkwo, UAK, Malekian, R & Maharaj, BT 2016, 'Molecular communication model for targeted drug delivery in multiple disease sites with diversely expressed enzymes', IEEE Transactions on Nanobioscience, vol. 15, no. 3, pp. 230-245. en_ZA
dc.identifier.issn 1536-1241 (print)
dc.identifier.issn 1558-2639 (online)
dc.identifier.other 10.1109/TNB.2016.2526783
dc.identifier.uri http://hdl.handle.net/2263/56153
dc.language.iso en en_ZA
dc.publisher Institute of Electrical and Electronics Engineers en_ZA
dc.rights © 2016 IEEE. Personal use is permitted, but republication/redistribution requires IEEE permission. en_ZA
dc.subject Molecular communication en_ZA
dc.subject Liposomes en_ZA
dc.subject Enzymes en_ZA
dc.subject Nanomedicine en_ZA
dc.subject Targeted drug delivery (TDD) en_ZA
dc.title Molecular communication model for targeted drug delivery in multiple disease sites with diversely expressed enzymes en_ZA
dc.type Postprint Article en_ZA


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