Activity of 7-methyljuglone derivatives against Mycobacterium tuberculosis and as subversive substrates for mycothiol disulfide reductase

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dc.contributor.author Mahapatra, Anita
dc.contributor.author Mativandlela, S.P.N. (Sannah Patience Nkami)
dc.contributor.author Binneman, Brigitte
dc.contributor.author Fourie, P.B. (Petrus Bernardus)
dc.contributor.author Hamilton, Chris J.
dc.contributor.author Meyer, J.J.M. (Jacobus Johannes Marion)
dc.contributor.author Van der Kooy, Frank
dc.contributor.author Houghton, P.J. (Peter James)
dc.contributor.author Lall, Namrita
dc.date.accessioned 2008-05-27T10:34:11Z
dc.date.available 2008-05-27T10:34:11Z
dc.date.issued 2007-12
dc.description.abstract The naphthoquinone 7-methyljuglone (5-hydroxy-7-methyl-1,4-naphthoquinone) has previously been isolated and identified as an active component of root extracts of Euclea natalensis which displays antitubercular activity. Herein, a series of synthetic and plant-derived naphthoquinone derivates of the 7-methyljuglone scaffold have been prepared and evaluated for antibacterial activity against Mycobacterium tuberculosis. Several of these compounds have been shown to operate as subversive substrates with mycothiol disulfide reductase. The absence of a direct correlation between antitubercular activity and subversive substrate efficiency with mycothiol disulfide reductase, might be a consequence of their non-specific reactivity with multiple biological targets (e.g. other disulfide reductases). en
dc.format.extent 361987 bytes
dc.format.mimetype application/pdf
dc.identifier.citation Mahapatra, A, Mativandlela, SPN, Binneman, B, Fourie, PB, Hamilton, CJ, Meyer, JJM, Van der Kooy, F, Houghton, P & Lall, N 2007, ‘Activity of 7-methyljuglone derivatives against Mycobacterium tuberculosis and as subversive substrates for mycothiol disulfide reductase’, Bioorganic & Medicinal Chemistry, vol.15, issue 24, pp. 7638-7646. [http://www.sciencedirect.com/science/journal/09680896] en
dc.identifier.issn 0968-0896
dc.identifier.other 10.1016/j.bmc.2007.08.064
dc.identifier.uri http://hdl.handle.net/2263/5604
dc.language.iso en en
dc.publisher Elsevier en
dc.rights Elsevier en
dc.subject Subversive substrates en
dc.subject Disulfide reductase en
dc.subject Mycothiol en
dc.subject Tuberculosis (TB) en
dc.subject.lcsh Mycobacterium tuberculosis en
dc.subject.lcsh Naphthoquinone en
dc.title Activity of 7-methyljuglone derivatives against Mycobacterium tuberculosis and as subversive substrates for mycothiol disulfide reductase en
dc.type Postprint Article en


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